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Japanese Journal of Radiology
Published in: Japanese Journal of Radiology 9/2018

01-09-2018 | Original Article

18F-FDG PET/CT can predict chemosensitivity and proliferation of epithelial ovarian cancer via SUVmax value

Authors: Shuai Liu, Zheng Feng, Hao Wen, Zhaoxia Jiang, Herong Pan, Yu Deng, Lei Zhang, Xingzhu Ju, Xiaojun Chen, Xiaohua Wu

Published in: Japanese Journal of Radiology | Issue 9/2018

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Abstract

Purpose

This study aimed to explore the clinical and prognostic significance of 18F-fluoro-2-deoxy-d-glucose positron emission tomography/computed tomography (18F-FDG PET/CT) in epithelial ovarian cancer (EOC).

Methods

We retrospectively investigated 48 EOC patients who underwent preoperative 18F-FDG PET/CT and primary cytoreductive surgery at our hospital between January 2010 and June 2015. None of these patients received neoadjuvant chemotherapy. PET/CT parameters including the maximum and average standardized uptake value (SUVmax, SUVavg), the metabolic tumor volume (MTV) were measured. Tumor proliferation marker Ki67 was evaluated using immunohistochemistry. The relationships between the PET/CT parameters and chemosensitivity, tumor proliferation, and overall survival (OS) were analyzed, respectively.

Results

The median (range) SUVmax, SUVavg, and MTV values were 11.42 (3.14–20.20), 4.8 (2.55–9.47), and 150.11 (0.19–792.46), respectively. Overall, 93.8% (45/48) of patients had high-grade serous ovarian cancer. The SUVmax value had a positive correlation with the Ki67 index (P = 0.030, r = 0.314), and a higher SUVmax level was associated with chemosensitivity (P = 0.026). However, neither SUVavg nor MTV had associations with the patients’ clinicopathological parameters. None of these three PET/CT parameters were found to be potential predictors of OS.

Conclusions

Preoperative 18F-FDG PET/CT had a predictive value on chemosensitivity and proliferation after primary debulking surgery in EOC patients noninvasively.
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Metadata
Title
18F-FDG PET/CT can predict chemosensitivity and proliferation of epithelial ovarian cancer via SUVmax value
Authors
Shuai Liu
Zheng Feng
Hao Wen
Zhaoxia Jiang
Herong Pan
Yu Deng
Lei Zhang
Xingzhu Ju
Xiaojun Chen
Xiaohua Wu
Publication date
01-09-2018
Publisher
Springer Japan
Published in
Japanese Journal of Radiology / Issue 9/2018
Print ISSN: 1867-1071
Electronic ISSN: 1867-108X
DOI
https://doi.org/10.1007/s11604-018-0755-y

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