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Japanese Journal of Radiology

Published in:

01-08-2017 | Original Article

Orbital malignant lesions in adults: multiparametric MR imaging

Authors: Bo Sun, Liyuan Song

Published in: Japanese Journal of Radiology | Issue 8/2017

Abstract

Purpose

To assess the benefit of combining diffusion-weighted imaging and dynamic contrast-enhanced (DCE) MR imaging in the preoperative evaluation of orbital lymphoma and other malignancies in adults.

Materials and methods

This retrospective study was institutional review board-approved and informed consent was waived. Pretreatment MR imaging was performed in 52 patients with malignant orbital lesions. Apparent diffusion coefficient (ADC) and DCE MR parameters were evaluated in 30 patients with orbital lymphoma and 22 patients with other orbital malignancies. Independent-samples t-test or Wilcoxon rank-sum test was used to compare parameters. The diagnostic capability was evaluated by using receiver operating characteristic curve (ROC) analysis.

Results

Lymphoma demonstrated significantly lower mean ADC (P < 0.001), T _max (P = 0.001), enhancement ratio (ER) (P < 0.001), contrast index (CI) (P < 0.001) and significantly higher washout ratio (WR) (P = 0.002) than other malignancies in the orbit. ROC analysis indicated that T _max alone or a combination with ADC and ER showed the optimal sensitivity (96.67%), a combination of ADC and WR showed optimal specificity (95.45%), while a combination of ADC and ER showed optimal accuracy (90.38%) in differentiating lymphoma from other malignancies.

Conclusion

Multiparametric MRI can help to differentiate orbital lymphoma and other malignancies.

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Title: Orbital malignant lesions in adults: multiparametric MR imaging
Authors: Bo Sun
Liyuan Song
Publication date: 01-08-2017
Publisher: Springer Japan
Published in: Japanese Journal of Radiology / Issue 8/2017
Print ISSN: 1867-1071
Electronic ISSN: 1867-108X
DOI: https://doi.org/10.1007/s11604-017-0653-8

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Orbital malignant lesions in adults: multiparametric MR imaging

Abstract

Purpose

Materials and methods

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Materials and methods

Results

Conclusion

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