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Japanese Journal of Radiology
Published in: Japanese Journal of Radiology 4/2017

01-04-2017 | Original Article

Temporal evolution of the signal intensity of hyper-acute ischemic lesions in a canine stroke model: influence of hyperintense acute reperfusion marker

Authors: Xiao-Quan Xu, Chen-Jiang Wu, Qing-Quan Zu, Shan-Shan Lu, Xing-Long Liu, Qian-Qian Gao, Sheng Liu, Hai-Bin Shi

Published in: Japanese Journal of Radiology | Issue 4/2017

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Abstract

Background

To assess the influence of the hyperintense acute reperfusion marker (HARM) on the relative signal intensity (rSI) and apparent diffusion coefficient (ADC) of hyper-acute ischemic lesions in a canine stroke model.

Methods

Middle cerebral artery occlusion models were established using autologous clot embolization. Diffusion-weighted (DW) and fluid-attenuated inversion recovery (FLAIR) imaging was performed at 1, 2, 3, 4.5 and 6 h after embolization. HARM was defined as the delayed enhancement of cerebrospinal fluid on the subsequent FLAIR images after contrast media used.

Results

Twenty-four stroke models were successfully established and divided into the HARM (n = 16) and No-HARM group (n = 8). No significant differences were found in the rSI on DWI (b0 and b1000 map) and relative ADC between the two groups at each time point after embolization (all P > 0.05). There were no significant differences in the rSI on FLAIR at 1 and 2 h after embolization between the two groups (P > 0.05), while the HARM group showed significantly higher rSI on FLAIR than the No-HARM group at 3, 4.5 and 6 h after embolization (P = 0.044, 0.036 and 0.001, respectively).

Conclusions

HARM should be noted during the quantitative analysis of FLAIR images in future clinical practice.
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Metadata
Title
Temporal evolution of the signal intensity of hyper-acute ischemic lesions in a canine stroke model: influence of hyperintense acute reperfusion marker
Authors
Xiao-Quan Xu
Chen-Jiang Wu
Qing-Quan Zu
Shan-Shan Lu
Xing-Long Liu
Qian-Qian Gao
Sheng Liu
Hai-Bin Shi
Publication date
01-04-2017
Publisher
Springer Japan
Published in
Japanese Journal of Radiology / Issue 4/2017
Print ISSN: 1867-1071
Electronic ISSN: 1867-108X
DOI
https://doi.org/10.1007/s11604-017-0615-1

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