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Japanese Journal of Radiology
Published in: Japanese Journal of Radiology 10/2016

01-10-2016 | Original Article

Evaluation of the degree of pancreatic fatty infiltration by area-based assessment of CT images: comparison with histopathology-based and CT attenuation index-based assessments

Authors: Mika Hori, Hiroaki Onaya, Nobuyoshi Hiraoka, Taiki Yamaji, Hideaki Kobayashi, Mami Takahashi, Michihiro Mutoh, Kazuaki Shimada, Hitoshi Nakagama

Published in: Japanese Journal of Radiology | Issue 10/2016

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Abstract

Purpose

The purpose of this study was to evaluate the degree of fatty infiltration (FI) of the pancreas using area-based assessment on computed tomography (CT) (CT area-based assessment) in its correlation and agreement/concordance with histopathology-based assessment. Furthermore, we examined whether CT area-based assessment was better than CT attenuation index-based assessment.

Materials and methods

We retrospectively evaluated the degree of FI of the pancreas in 37 pancreatic cancer patients who had undergone preoperative CT and pancreaticoduodenectomy. The degree of FI of the pancreas was examined by histopathology-based assessment using surgical resection samples, and CT area-based and CT attenuation index-based assessments.

Results

Mean values of pancreatic FI measured by area-based assessment on unenhanced CT and by histopathology-based assessments were 14.4 ± 23.2 % (range 0–77.7 %) and 16.2 ± 17.4 % (range 0.2–60.2 %), respectively. Area-based assessment on unenhanced CT showed higher correlation and concordance with histopathology-based assessment, demonstrating a Spearman correlation coefficient of 0.78 (P < 0.0001) and a Kendall’s tau-b coefficient of 0.69 (P < 0.0001). For CT attenuation index-based assessment, the corresponding values were −0.66 (P < 0.0001) and −0.39 (P = 0.008), respectively.

Conclusions

To order/categorize subjects according to the degree of FI of the pancreas, CT area-based assessment is suggested to be better than CT attenuation index-based assessment.
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Metadata
Title
Evaluation of the degree of pancreatic fatty infiltration by area-based assessment of CT images: comparison with histopathology-based and CT attenuation index-based assessments
Authors
Mika Hori
Hiroaki Onaya
Nobuyoshi Hiraoka
Taiki Yamaji
Hideaki Kobayashi
Mami Takahashi
Michihiro Mutoh
Kazuaki Shimada
Hitoshi Nakagama
Publication date
01-10-2016
Publisher
Springer Japan
Published in
Japanese Journal of Radiology / Issue 10/2016
Print ISSN: 1867-1071
Electronic ISSN: 1867-108X
DOI
https://doi.org/10.1007/s11604-016-0572-0

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