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01-12-2014 | Original Article

Clinical utility of the normalized apparent diffusion coefficient for preoperative evaluation of the aggressiveness of prostate cancer

Authors: Ryo Itatani, Tomohiro Namimoto, Akira Yoshimura, Kazuhiro Katahira, Seiichiro Noda, Nobuyuki Toyonari, Kosuke Kitani, Yasuyuki Hamada, Mitsuhiko Kitaoka, Yasuyuki Yamashita

Published in: Japanese Journal of Radiology | Issue 12/2014

Abstract

Purpose

Normalization of the apparent diffusion coefficient (ADC) may overcome ADC variability attributable to different patient and/or technical factors. The purpose of this study was to compare the efficacy of ADC and the normalized ADC (nADC) for differentiating between prostate cancer with a Gleason score (GS) = 6 and GS > 6 and to identify an optimum reference for nADC calculations.

Materials and methods

Our study population comprised 58 patients who underwent diffusion-weighted MRI followed by radical prostatectomy. The nADC of the prostate cancer was calculated as ADC (cancer)/ADC (reference) by using the obturator internus muscle, urine in the bladder, and a 20-ml saline bottle placed on the groin as references. We performed receiver operating characteristic (ROC) analysis to identify the optimum reference for nADC calculations.

Results

To differentiate between GS = 6 and GS > 6 prostate cancer, the area under the ROC curve of the nADC obtained with a saline bottle as reference was best (0.85) and significantly better than the area under the ADC ROC curve (0.71).

Conclusions

nADC is superior to ADC for estimating the aggressiveness of prostate cancer. It is a noninvasive technique that aids in the selection of appropriate treatments.

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Title: Clinical utility of the normalized apparent diffusion coefficient for preoperative evaluation of the aggressiveness of prostate cancer
Authors: Ryo Itatani
Tomohiro Namimoto
Akira Yoshimura
Kazuhiro Katahira
Seiichiro Noda
Nobuyuki Toyonari
Kosuke Kitani
Yasuyuki Hamada
Mitsuhiko Kitaoka
Yasuyuki Yamashita
Publication date: 01-12-2014
Publisher: Springer Japan
Published in: Japanese Journal of Radiology / Issue 12/2014
Print ISSN: 1867-1071
Electronic ISSN: 1867-108X
DOI: https://doi.org/10.1007/s11604-014-0367-0

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Clinical utility of the normalized apparent diffusion coefficient for preoperative evaluation of the aggressiveness of prostate cancer

Abstract

Purpose

Materials and methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Materials and methods

Results

Conclusions

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