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01-06-2014 | Original Article

Neointimal hyperplasia after stent placement across size-discrepant vessels in an animal study

Authors: Hisayuki Cho, Mineyoshi Nango, Yukimasa Sakai, Etsuji Sohgawa, Ken Kageyama, Shinichi Hamamoto, Toshiaki Kitayama, Akira Yamamoto, Yukio Miki

Published in: Japanese Journal of Radiology | Issue 6/2014

Abstract

Purpose

To examine differences in neointimal hyperplasia (NIH) after placing a self-expanding (SE) stent across size-discrepant vessels.

Materials and methods

The subjects were 6 beagles, and the target vessels were the abdominal aorta and the external iliac artery (EIA). A nitinol SE stent was placed which was normal-sized in the aorta and oversized in the EIA. Angiography and intravascular ultrasound (IVUS) were performed immediately and after 1 and 3 months; histopathologic examinations were then performed. Furthermore, the chronic outward force (COF) on the same type of stent was investigated in vitro.

Results

On IVUS, thickened intima was seen on the EIA at 1 month (5.1 ± 4.2 mm²) and at 3 months (7.8 ± 2.5 mm²). For the aorta, thickening of the intima was negligible at any time. Histopathologically, the percentage of the vessel obliterated by NIH was significantly greater on the iliac side than on the aortic side (33.2 ± 10.4 vs. 13.4 ± 4.4 %). The COF exerted when stent diameter reached that of the EIA and the aorta was 0.73 and 0.17 N/mm², respectively.

Conclusions

When a non-tapered stent is placed in vessels with a large discrepancy in diameter, attention must be paid to increased NIH in the oversized side.

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Title: Neointimal hyperplasia after stent placement across size-discrepant vessels in an animal study
Authors: Hisayuki Cho
Mineyoshi Nango
Yukimasa Sakai
Etsuji Sohgawa
Ken Kageyama
Shinichi Hamamoto
Toshiaki Kitayama
Akira Yamamoto
Yukio Miki
Publication date: 01-06-2014
Publisher: Springer Japan
Published in: Japanese Journal of Radiology / Issue 6/2014
Print ISSN: 1867-1071
Electronic ISSN: 1867-108X
DOI: https://doi.org/10.1007/s11604-014-0311-3

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Springer Medicine

Neointimal hyperplasia after stent placement across size-discrepant vessels in an animal study

Abstract

Purpose

Materials and methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Materials and methods

Results

Conclusions

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