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International Journal of Computer Assisted Radiology and Surgery

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Open Access 01-04-2018 | Original Article

Landmark-based evaluation of a deformable motion correction for DCE-MRI of the liver

Authors: Jan Strehlow, Nadine Spahr, Jan Rühaak, Hendrik Laue, Nasreddin Abolmaali, Tobias Preusser, Andrea Schenk

Published in: International Journal of Computer Assisted Radiology and Surgery | Issue 4/2018

Abstract

Purpose

Annotation of meaningful landmark ground truth on DCE-MRI is difficult and laborious. Motion correction methods applied to DCE-MRI of the liver are thus mostly evaluated using qualitative or indirect measures. We propose a novel landmark annotation scheme that facilitates the generation of landmark ground truth on larger clinical datasets.

Methods

In our annotation scheme, landmarks are equally distributed over all time points of all available dataset cases and annotated by multiple observers on a per-pair basis. The scheme is used to annotate 26 DCE-MRI of the liver. A subset of the ground truth is used to optimize parameters of a deformable motion correction. Several variants of the motion correction are evaluated on the remaining cases with respect to distances of corresponding landmarks after registration, deformation field properties, and qualitative measures.

Results

A landmark ground truth on 26 cases could be generated in under 12 h per observer with a mean inter-observer distance below the mean voxel diagonal. Furthermore, the landmarks are spatially well distributed within the liver. Parameter optimization significantly improves the performance of the motion correction, and landmark distance after registration is 2 mm. Qualitative evaluation of the motion correction reflects the quantitative results.

Conclusions

The annotation scheme makes a landmark-based evaluation of motion corrections for hepatic DCE-MRI practically feasible for larger clinical datasets. The comparably large number of cases enables both optimization and evaluation of motion correction methods.

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Title: Landmark-based evaluation of a deformable motion correction for DCE-MRI of the liver
Authors: Jan Strehlow
Nadine Spahr
Jan Rühaak
Hendrik Laue
Nasreddin Abolmaali
Tobias Preusser
Andrea Schenk
Publication date: 01-04-2018
Publisher: Springer International Publishing
Published in: International Journal of Computer Assisted Radiology and Surgery / Issue 4/2018
Print ISSN: 1861-6410
Electronic ISSN: 1861-6429
DOI: https://doi.org/10.1007/s11548-018-1710-1

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Landmark-based evaluation of a deformable motion correction for DCE-MRI of the liver

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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