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01-12-2018 | CARDIAC RADIOLOGY

T1 and T2 mapping in the identification of acute myocardial injury in patients with NSTEMI

Authors: Carlo Tessa, Jacopo Del Meglio, Alessio Lilli, Stefano Diciotti, Luca Salvatori, Marco Giannelli, Andreas Greiser, Claudio Vignali, Giancarlo Casolo

Published in: La radiologia medica | Issue 12/2018

Abstract

Aims

To test T1 and T2 mapping in the assessment of acute myocardial injury in patients with non-ST-segment elevation myocardial infarction (NSTEMI), evaluated before revascularization.

Methods

Forty-seven patients with acute NSTEMI underwent cardiac magnetic resonance (CMR) at 1.5 T, including T1 and T2 mapping.

Results

Coronary angiography (CA) evidenced an obstructive coronary artery disease (CAD) in 36 patients (80%) and a non-obstructive CAD in 11 patients (20%). Edema was detected in 51.1/65.9% of patients in T1/T2 maps, respectively. This difference was due to artifacts in T1 maps. T1/T2 values were significantly higher in the infarcted myocardium (IM) compared with the remote myocardium (RM) (in T1: 1151.6 ± 53.5 ms vs. 958.2 ± 38.6 ms, respectively; in T2: 69 ± 6 ms vs. 51.9 ± 2.9 ms, respectively; p < 0.0001 for both). We found both an obstructive CAD at CA and myocardial edema at CMR in 53.2% of patients, while 8.5% of patients had a non-obstructive CAD and no edema. However, 25.5% of patients had an obstructive CAD without edema, while 12.8% of patients showed edema despite a non-obstructive CAD. Furthermore, in 6 of the edema-positive patients with multi-vessels obstructive CAD, CMR identified myocardial edema in a vascular territory different from that of the lesion supposed to be the culprit at CA.

Conclusions

In a non-negligible percentage of NSTEMI patients, T1 and T2 mapping detect myocardial edema without significant stenosis at CA and vice versa. Therefore, CA and CMR edema imaging might provide complementary information in the evaluation of NSTEMI.

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Title: T1 and T2 mapping in the identification of acute myocardial injury in patients with NSTEMI
Authors: Carlo Tessa
Jacopo Del Meglio
Alessio Lilli
Stefano Diciotti
Luca Salvatori
Marco Giannelli
Andreas Greiser
Claudio Vignali
Giancarlo Casolo
Publication date: 01-12-2018
Publisher: Springer Milan
Published in: La radiologia medica / Issue 12/2018
Print ISSN: 0033-8362
Electronic ISSN: 1826-6983
DOI: https://doi.org/10.1007/s11547-018-0931-2

At a glance: The STEP trials

Springer Medicine

T1 and T2 mapping in the identification of acute myocardial injury in patients with NSTEMI

Abstract

Aims

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Aims

Methods

Results

Conclusions

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