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Targeted Oncology
Published in: Targeted Oncology 3/2017

01-06-2017 | Review Article

Cancer Immunotherapy with Cytokine-Induced Killer Cells

Authors: Juan J. Mata-Molanes, Manuel Sureda González, Belén Valenzuela Jiménez, Elena Mª Martínez Navarro, Antonio Brugarolas Masllorens

Published in: Targeted Oncology | Issue 3/2017

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Abstract

Cytokine-induced killer (CIK) cells form under certain stimulation conditions in cultures of peripheral blood mononuclear cells (PBMCs). They are a heterogeneous immune cell population and contain a high percentage of cells with a mixed T-NK phenotype (CD3+CD56+). The ready availability of a lymphocyte source, together with the high proliferative rate and potent anti-tumor activity of CIK cells, has allowed their use as immunotherapy in a wide variety of neoplasms. Cytotoxicity mediated by CD3+CD56+ T cells depends on the major histocompatibility antigen (MHC)-independent recognition of tumor cells and the activation of signaling pathways through the natural killer group 2 member D (NKG2D) cell-surface receptor. Clinical trials have demonstrated the feasibility and efficacy of CIK cell immunotherapy even in advanced stage cancer patients or those that have not responded to first-line treatment. This review summarizes biological and technical aspects of CIK cells, as well as past and current clinical trials and future trends in this form of immunotherapy.
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Metadata
Title
Cancer Immunotherapy with Cytokine-Induced Killer Cells
Authors
Juan J. Mata-Molanes
Manuel Sureda González
Belén Valenzuela Jiménez
Elena Mª Martínez Navarro
Antonio Brugarolas Masllorens
Publication date
01-06-2017
Publisher
Springer International Publishing
Published in
Targeted Oncology / Issue 3/2017
Print ISSN: 1776-2596
Electronic ISSN: 1776-260X
DOI
https://doi.org/10.1007/s11523-017-0489-2

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