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01-02-2012 | HSS Osteoarthritis Symposium: Frontiers in OA

Pathologic and Pathogenic Processes in Osteoarthritis: The Effects of Synovitis

Author: Carla R. Scanzello, MD, PhD

Published in: HSS Journal ® | Issue 1/2012

Excerpt

Synovitis (inflammation of the synovial lining) is increasingly recognized as a characteristic of the osteoarthritic joint. Over the past decade, many have documented that synovitis is present in various stages of the disease and is detectable by advanced imaging techniques [3], the presence of soluble mediators [5], or histopathologic assessment [9]. Despite using different methods of detection and different outcome measurements, studies from these multiple research groups have often led to similar conclusions. …

Ashraf, S., Mapp, P. I., and Walsh, D. A. Contributions of angiogenesis to inflammation, joint damage, and pain in a rat model of osteoarthritis. Arthritis Rheum 63:2700–10; 2011.PubMedCrossRef

Ayral, X., Pickering, E. H., Woodworth, T. G., Mackillop, N., and Dougados, M. Synovitis: a potential predictive factor of structural progression of medial tibiofemoral knee osteoarthritis -- results of a 1 year longitudinal arthroscopic study in 422 patients. Osteoarthritis Cartilage 13:361–7; 2005.PubMedCrossRef

Guermazi, A., Roemer, F. W., Hayashi, D., Crema, M. D., Niu, J., Zhang, Y., Marra, M. D., Katur, A., Lynch, J. A., El-Khoury, G. Y., Baker, K., Hughes, L. B., Nevitt, M. C., and Felson, D. T. Assessment of synovitis with contrast-enhanced MRI using a whole-joint semiquantitative scoring system in people with, or at high risk of, knee osteoarthritis: the MOST study. Ann Rheum Dis 70:805–11; 2011.PubMedCrossRef

Hunter, D. J., Zhang, W., Conaghan, P. G., Hirko, K., Menashe, L., Reichmann, W. M., and Losina, E. Responsiveness and reliability of MRI in knee osteoarthritis: a meta-analysis of published evidence. Osteoarthritis Cartilage 19:589–605; 2011.PubMedCrossRef

Ishijima, M., Watari, T., Naito, K., Kaneko, H., Futami, I., Yoshimura-Ishida, K., Tomonaga, A., Yamaguchi, H., Yamamoto, T., Nagaoka, I., Kurosawa, H., Poole, R. A., and Kaneko, K. Relationships between biomarkers of cartilage, bone, synovial metabolism and knee pain provide insights into the origins of pain in early knee osteoarthritis. Arthritis Res Ther 13:R22; 2011.PubMedCrossRef

Krasnokutsky, S., Belitskaya-Levy, I., Bencardino, J., Samuels, J., Attur, M., Regatte, R., Rosenthal, P., Greenberg, J., Schweitzer, M., Abramson, S. B., and Rybak, L. Quantitative magnetic resonance imaging evidence of synovial proliferation is associated with radiographic severity of knee osteoarthritis. Arthritis Rheum 63:2983–91; 2011.PubMedCrossRef

Ling, S. M., Patel, D. D., Garnero, P., Zhan, M., Vaduganathan, M., Muller, D., Taub, D., Bathon, J. M., Hochberg, M., Abernethy, D. R., Metter, E. J., and Ferrucci, L. Serum protein signatures detect early radiographic osteoarthritis. Osteoarthritis Cartilage 17:43–8; 2009.PubMedCrossRef

Pearle, A. D., Scanzello, C. R., George, S., Mandl, L. A., DiCarlo, E. F., Peterson, M., Sculco, T. P., and Crow, M. K. Elevated high-sensitivity C-reactive protein levels are associated with local inflammatory findings in patients with osteoarthritis. Osteoarthritis Cartilage 15:516–23; 2007.PubMedCrossRef

Pessler, F., Dai, L., Diaz-Torne, C., Gomez-Vaquero, C., Paessler, M. E., Zheng, D. H., Einhorn, E., Range, U., Scanzello, C., and Schumacher, H. R. The synovitis of "non-inflammatory" orthopaedic arthropathies: a quantitative histological and immunohistochemical analysis. Ann Rheum Dis 67:1184–7; 2008.PubMedCrossRef

10.

Roemer, F. W., Zhang, Y., Niu, J., Lynch, J. A., Crema, M. D., Marra, M. D., Nevitt, M. C., Felson, D. T., Hughes, L. B., El-Khoury, G. Y., Englund, M., and Guermazi, A. Tibiofemoral joint osteoarthritis: risk factors for MR-depicted fast cartilage loss over a 30-month period in the multicenter osteoarthritis study. Radiology 252:772–80; 2009.PubMedCrossRef

11.

Scanzello, C. R., McKeon, B., Swaim, B. H., DiCarlo, E., Asomugha, E. U., Kanda, V., Nair, A., Lee, D. M., Richmond, J. C., Katz, J. N., Crow, M. K., and Goldring, S. R. Synovial inflammation in patients undergoing arthroscopic meniscectomy: molecular characterization and relationship to symptoms. Arthritis Rheum 63:391–400; 2011.PubMedCrossRef

12.

Scanzello, C. R., Umoh, E., Pessler, F., Diaz-Torne, C., Miles, T., Dicarlo, E., Potter, H. G., Mandl, L., Marx, R., Rodeo, S., Goldring, S. R., and Crow, M. K. Local cytokine profiles in knee osteoarthritis: elevated synovial fluid interleukin-15 differentiates early from end-stage disease. Osteoarthritis Cartilage 17:1040–8; 2009.PubMedCrossRef

13.

Sowers, M., Karvonen-Gutierrez, C. A., Jacobson, J. A., Jiang, Y., and Yosef, M. Associations of anatomical measures from MRI with radiographically defined knee osteoarthritis score, pain, and physical functioning. J Bone Joint Surg Am 93:241–51; 2011.PubMedCrossRef

Title: Pathologic and Pathogenic Processes in Osteoarthritis: The Effects of Synovitis
Author: Carla R. Scanzello, MD, PhD
Publication date: 01-02-2012
Publisher: Springer-Verlag
Published in: HSS Journal ® / Issue 1/2012
Print ISSN: 1556-3316
Electronic ISSN: 1556-3324
DOI: https://doi.org/10.1007/s11420-011-9228-x

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