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Forensic Toxicology

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Open Access 01-01-2020 | Benzodiazepine | Case Report

Identification of the designer benzodiazepine 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine (flualprazolam) in an anesthesia robbery case

Authors: Zhenhua Qian, Cuimei Liu, Jian Huang, Qingqing Deng, Zhendong Hua

Published in: Forensic Toxicology | Issue 1/2020

Abstract

Purpose

This publication reports analytical properties of the designer benzodiazepine 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine (flualprazolam) seized in an anesthesia robbery case.

Methods

The target compound was identified by liquid chromatography–quadrupole time-of-flight-mass spectrometry (LC–QTOF-MS), gas chromatography–mass spectrometry (GC–MS), and nuclear magnetic resonance (NMR) spectroscopy.

Results

We could obtain detailed analytical data of flualprazolam—a new designer benzodiazepine available on the designer drug market.

Conclusions

More designer benzodiazepines have been detected and seized on the illegal drug scene as new psychoactive substances during the last 5 years. In this study, we presented analytical data of flualprazolam to assist forensic laboratories that encounter these newly emerging compounds in casework. This is the first report on this compound in illegal products.

United Nations Office on Drugs and Crime (UNODC) (2019) Current NPS threats, vol. I March 2019. https://www.unodc.org/pdf/opioids-crisis/Current_NPS_Threats_-_Volume_I.pdf. Accessed 6 Mar 2019

United Nations Office on Drugs and Crime (UNODC) (2013) The challenge of new psychoactive substances. https://www.unodc.org/documents/scientific/NPS_2013_SMART.pdf. Accessed Mar 2013

Manchester KR, Lomas EC, Waters L, Dempsey FC, Maskell PD (2018) The emergence of new psychoactive substance (NPS) benzodiazepines: a review. Drug Test Anal 10:37–53. https://doi.org/10.1002/dta.2211 CrossRefPubMed

Moosmann B, King LA, Auwärter V (2015) Designer benzodiazepines: a new challenge. World Psychiatry 14:248. https://doi.org/10.1002/wps.20236 (open access article)CrossRefPubMedPubMedCentral

European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) (2010) Benzodiazepines drug profile. https://www.emcdda.europa.eu/publications/drug-profiles/benzodiazepine. Accessed 20 May 2019

Bachhuber MA, Hennessy S, Cunningham CO, Starrels JL (2016) Increasing benzodiazepine prescriptions and overdose mortality in the United States, 1996–2013. Am J Public Health 106:686–688. https://doi.org/10.2105/AJPH.2016.303061 CrossRefPubMedPubMedCentral

Kapil V, Green JL, Le Lait C, Wood DM, Dargan PI (2014) Misuse of benzodiazepines and Z-drugs in the UK. Br J Psychiatry 205:407–408. https://doi.org/10.1192/bjp.bp.114.149252 CrossRefPubMed

Huppertz LM, Bisel P, Westphal F, Franz F, Auwärter V, Moosmann B (2015) Characterization of the four designer benzodiazepines clonazolam, deschloroetizolam, flubromazolam, and meclonazepam, and identification of their in vitro metabolites. Forensic Toxicol 33:388–395. https://doi.org/10.1007/s11419-015-0277-6 CrossRef

Łukasik-Głębocka M, Sommerfeld K, Teżyk A, Zielińska-Psuja B, Panieński P, Żaba C (2016) Flubromazolam—a new life-threatening designer benzodiazepine. Clin Toxicol 54:66–68. https://doi.org/10.3109/15563650.2015.1112907 CrossRef

10.

Hester JB Jr (1970) Sedative and antispasmodic 6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepines. DE 2012190, US 3701782

11.

SciFinder (2019) American Chemical Society. https://scifinder.cas.org. Accessed 20 May 2019

12.

Pretsch E, Bühlmann P, Badertscher M (2009) Structure determination of organic compounds: tables of spectral data, 4th edn. Springer, Berlin, pp 102–103

Title: Identification of the designer benzodiazepine 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine (flualprazolam) in an anesthesia robbery case
Authors: Zhenhua Qian
Cuimei Liu
Jian Huang
Qingqing Deng
Zhendong Hua
Publication date: 01-01-2020
Publisher: Springer Singapore
Keyword: Benzodiazepine
Published in: Forensic Toxicology / Issue 1/2020
Print ISSN: 1860-8965
Electronic ISSN: 1860-8973
DOI: https://doi.org/10.1007/s11419-019-00501-1

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Identification of the designer benzodiazepine 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine (flualprazolam) in an anesthesia robbery case

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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