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Forensic Toxicology
Published in: Forensic Toxicology 1/2018

01-01-2018 | Letter to the Editor

A modified direct-heating headspace solid-phase microextraction method for drug screening with urine samples

Authors: Hiroshi Fujii, Brian Waters, Kenji Hara, Natsuki Ikematsu, Mio Takayama, Aya Matsusue, Masayuki Kashiwagi, Shin-ichi Kubo

Published in: Forensic Toxicology | Issue 1/2018

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Excerpt

In forensic autopsy cases, it is important to quickly identify the drugs and chemicals that caused poisoning in humans. Previously, we reported a direct-heating headspace solid-phase microextraction (DH-HS-SPME) method for the screening of illicit drugs [1]. The DH-HS-SPME has an advantage in that volatile to non-volatile compounds can be adsorbed to the SPME fiber in the headspace vial that enables comprehensive screening of compounds by gas chromatography–mass spectrometry (GC–MS). In this letter, we present application of this DH-HS-SPME method to actual urine samples from suspects of drug abuse together with some modifications to enhance its sensitivity. …
Literature
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Hara K, Waters B, Ikematsu N, Tokuyasu T, Fujii H, Takayama M, Matsusue A, Kashiwagi M, Kubo S (2016) Development of a preparation method to produce a single sample that can be applied to both LC–MS/MS and GC–MS for the screening of postmortem specimens. Leg Med 21:85–92CrossRef
Metadata
Title
A modified direct-heating headspace solid-phase microextraction method for drug screening with urine samples
Authors
Hiroshi Fujii
Brian Waters
Kenji Hara
Natsuki Ikematsu
Mio Takayama
Aya Matsusue
Masayuki Kashiwagi
Shin-ichi Kubo
Publication date
01-01-2018
Publisher
Springer Japan
Published in
Forensic Toxicology / Issue 1/2018
Print ISSN: 1860-8965
Electronic ISSN: 1860-8973
DOI
https://doi.org/10.1007/s11419-017-0396-3

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