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01-06-2020 | Note

Three new steroidal saponins from Aspidistra letreae plants and their cytotoxic activities

Authors: Duc Viet Ho, Hanh Nhu Thi Hoang, Hung Quoc Vo, Khan Viet Nguyen, Ty Viet Pham, Anh Tuan Le, Kiem Van Phan, Hien Minh Nguyen, Hiroyuki Morita, Hoai Thi Nguyen

Published in: Journal of Natural Medicines | Issue 3/2020

Abstract

Three new steroidal saponins, aspiletreins A–C (1–3), together with 2H-chromen-2-one (4), and α-tocopherol (5), were isolated from whole Aspidistra letreae plants collected in Vietnam. Their structures were elucidated by a combination of spectroscopic analyses, including 1D- and 2D-NMR, IR, and HRESIMS, and by comparison with the reported data in the literature. Compounds 1–3 exhibited moderate cytotoxicities against the LU-1, HeLa, MDA-MB-231, HepG2, and MKN-7 human cancer cell lines, with IC₅₀ values ranging from 7.69 ± 0.40 to 20.46 ± 3.11 µM.

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Title: Three new steroidal saponins from Aspidistra letreae plants and their cytotoxic activities
Authors: Duc Viet Ho
Hanh Nhu Thi Hoang
Hung Quoc Vo
Khan Viet Nguyen
Ty Viet Pham
Anh Tuan Le
Kiem Van Phan
Hien Minh Nguyen
Hiroyuki Morita
Hoai Thi Nguyen
Publication date: 01-06-2020
Publisher: Springer Singapore
Published in: Journal of Natural Medicines / Issue 3/2020
Print ISSN: 1340-3443
Electronic ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-020-01395-9

At a glance: The STEP trials

Springer Medicine

Three new steroidal saponins from Aspidistra letreae plants and their cytotoxic activities

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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