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01-06-2019 | Alogliptin | Original Paper

Salacia chinensis stem extract and its thiosugar sulfonium constituent, neokotalanol, improves HbA1c levels in ob/ob mice

Authors: Masakazu Kobayashi, Junji Akaki, Yasuyo Yamaguchi, Hiroo Yamasaki, Kiyofumi Ninomiya, Yutana Pongpiriyadacha, Masayuki Yoshikawa, Osamu Muraoka, Toshio Morikawa

Published in: Journal of Natural Medicines | Issue 3/2019

Abstract

The antidiabetic effects of a hot water extract of the stems of Salacia chinensis (SCE) were evaluated in vivo in ob/ob mice (genetically obese hyperglycemic mice). Administration of dietary feed containing 0.20 and 0.50% of SCE for 23 days to ob/ob mice significantly suppressed the elevation of both blood glucose and HbA1c levels, without significantly changing body weight and food intake. To characterize the antidiabetic effects of the thiosugar sulfonium constituent neokotalanol (1), which has potent α-glucosidase inhibitory activity, we performed a similar in vivo study. HbA1c levels were significantly suppressed in ob/ob mice after the administration of dietary feed containing 0.0003% of neokotalanol (1) for 20 days. These results indicate that SCE and neokotalanol (1) are potential leads for the development of novel antidiabetic agents.

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Title: Salacia chinensis stem extract and its thiosugar sulfonium constituent, neokotalanol, improves HbA1c levels in ob/ob mice
Authors: Masakazu Kobayashi
Junji Akaki
Yasuyo Yamaguchi
Hiroo Yamasaki
Kiyofumi Ninomiya
Yutana Pongpiriyadacha
Masayuki Yoshikawa
Osamu Muraoka
Toshio Morikawa
Publication date: 01-06-2019
Publisher: Springer Singapore
Keyword: Alogliptin
Published in: Journal of Natural Medicines / Issue 3/2019
Print ISSN: 1340-3443
Electronic ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-019-01311-w

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Salacia chinensis stem extract and its thiosugar sulfonium constituent, neokotalanol, improves HbA1c levels in ob/ob mice

Abstract

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

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