Top

Published in:

01-01-2019 | Note

Sedative effects of the essential oil and headspace air of Ocimum basilicum by inhalation in mice

Authors: Miho Hirai, Michiho Ito

Published in: Journal of Natural Medicines | Issue 1/2019

Abstract

The sedative effects of the essential oil released by living Ocimum basilicum (basil) plants were investigated using a mouse activity monitoring system. Ocimum basilicum plants were grown in a hydroponic chamber, and either the headspace air from the hydroponic chamber or the essential oil extracted from mature plants was administered by the inhalation route to mice in an open field test. The most effective dose of O. basilicum essential oil for reducing the locomotor activity of the mice was found to be 4.0 × 10⁻³ mg per cage. The headspace air was administered to mice held in a glass cage via a Teflon tube connected to a hydroponic chamber containing O. basilicum plants. A significant decrease in locomotor activity was observed when the hydroponic chamber contained nine plants. The results of this study demonstrate that the headspace air of living basil plants could effectively reduce the locomotor activity of mice.

Tankam JM, Ito M (2014) Sedative, anxiolytic and antidepressant-like effects of inhalation of the essential oil of Ocimum gratissimum L. from Cameroon in mice. J Pharmacogn Phytochem 2(5):1–9

Ogawa K, Ito M (2016) Appetite-enhancing effects of curry oil. Biol Pharm Bull 39(9):1559–1563CrossRef

Elansary HO, Mahmoud EA (2015) Basil cultivar identification using chemotyping still favored over genotyping using core barcodes and possible resources of antioxidants. J Essent Oil Res 27(1):82–87CrossRef

Tankam JM, Ito M (2013) Inhalation of the essential oil of Piper guineense from Cameroon shows sedative and anxiolytic-like effects in mice. Biol Pharm Bull 36(10):1608–1614CrossRef

Ogawa K, Miyoshi T, Kitayama T, Ito M (2014) Locomotor-reducing effects and structural characteristics of inhaled zerumbone and tetrahydrozerumbone derivatives. Biol Pharm Bull 37(9):1559–1563CrossRef

Fujiwara Y, Ito M (2011) Synergistic effect of fragrant herbs in Japanese scent sachets. Planta Med 81:193–199

Nascimento JC, Barbosa LC, Paula VF, David JM, Fontana R, Silva LA, França RS (2011) Chemical composition and antimicrobial activity of essential oils of Ocimum canum Sims and Ocimum selloi Benth. An Acad Bras Cienc 83(3):787–799CrossRef

Takemoto H, Ito M, Shiraki T, Yagura T, Honda G (2008) Sedative effects of vapor inhalation of agarwood oil and spikenard extract and identification of their active components. J Nat Med 62:41–46CrossRef

Title: Sedative effects of the essential oil and headspace air of Ocimum basilicum by inhalation in mice
Authors: Miho Hirai
Michiho Ito
Publication date: 01-01-2019
Publisher: Springer Singapore
Published in: Journal of Natural Medicines / Issue 1/2019
Print ISSN: 1340-3443
Electronic ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-018-1253-3

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Sedative effects of the essential oil and headspace air of Ocimum basilicum by inhalation in mice

Abstract

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 1/2019

Screening for natural medicines effective for the treatment of osteoporosis

Preventive agents for neurodegenerative diseases from resin of Dracaena cochinchinensis attenuate LPS-induced microglia over-activation

Pregnane glycosides from the bark of Marsdenia cundurango and their cytotoxic activity

Aloin promotes osteogenesis of bone-marrow-derived mesenchymal stem cells via the ERK1/2-dependent Runx2 signaling pathway

Structure of constituents isolated from the bark of Cassipourea malosana and their cytotoxicity against a human ovarian cell line

Bioactive constituents obtained from the fruits of Citrus aurantium