Top

Published in:

01-06-2018 | Note

Determination of (E)-ferulic acid content in the root of Angelica acutiloba: a simple chemical evaluation method for crude drug quality control

Authors: Noriko Shinjyo, Hiroyuki Fuchino, Nobuo Kawahara, Atsuyuki Hishida

Published in: Journal of Natural Medicines | Issue 3/2018

Abstract

The root of Angelica acutiloba Kitagawa is an important crude drug in Kampo medicines (traditional Japanese medicine). Chemical evaluation of crude drugs is crucial to ensuring the safety and efficacy of herbal medicine; however, there is currently no chemical standard for the A. acutiloba crude drug in Japanese pharmacopoeia. (E)-ferulic acid (FA) is an important active ingredient of Angelica spp., including A. sinensis (Oliv.) Diels, and has been suggested as a marker for quality evaluation of those crude drugs. However, it has been controversial whether FA is a reliable marker constituent of A. acutiloba. To achieve effective extraction of FA from A. acutiloba, we compared three different extraction methods: alkaline hydrolysis, ethanol extraction, and hexane extraction. FA levels in these extracts were assessed using high performance liquid chromatography (HPLC), and alkaline hydrolysis was found to be the most effective. Furthermore, in the hydrolysate, FA was distinctly identified by thin layer chromatography (TLC) analysis. These results provide useful information for the quality control of the A. acutiloba crude drug.

Wei WL, Zeng R, Gu CM et al (2016) Angelica sinensis in China-A review of botanical profile, ethnopharmacology, phytochemistry and chemical analysis. J Ethnopharmacol 190:116–141CrossRef

Hook IL (2014) Danggui to Angelica sinensis root: are potential benefits to European women lost in translation? A review. J Ethnopharmacol 152:1–13CrossRef

Tarachiwin L, Katoh A, Ute K, Fukusaki E (2008) Quality evaluation of Angelica acutiloba Kitagawa roots by 1H NMR-based metabolic fingerprinting. J Pharm Biomed Anal 48:42–48CrossRef

Lu GH, Chan K, Liang YZ et al (2005) Development of high-performance liquid chromatographic fingerprints for distinguishing Chinese Angelica from related umbelliferae herbs. J Chromatogr A 1073:383–392. https://doi.org/10.1016/j.chroma.2004.11.080 CrossRefPubMed

Jeong SY, Kim HM, Lee KH et al (2015) Quantitative analysis of marker compounds in Angelica gigas, Angelica sinensis, and Angelica acutiloba by HPLC/DAD. Chem Pharm Bull 63:504–511CrossRef

Srinivasan M, Sudheer AR, Menon VP (2007) Ferulic acid: therapeutic potential through its antioxidant property. J Clin Biochem Nutr 40:92–100. https://doi.org/10.3164/jcbn.40.92 CrossRefPubMedPubMedCentral

Ghosh S, Basak P, Dutta S et al (2017) New insights into the ameliorative effects of ferulic acid in pathophysiological conditions. Food Chem Toxicol 103:41–55CrossRef

Kumar N, Pruthi V (2014) Potential applications of ferulic acid from natural sources. Biotechnol Reports 4:86–93CrossRef

Xie JJ, Lu J, Qian ZM et al (2009) Optimization and comparison of five methods for extraction of coniferyl ferulate from Angelica sinensis. Molecules 14:555–565CrossRef

10.

Jankovska P, Copikova J, Sinitsya A (2001) The determination of ferulic acid in sugar beet pulp. Czech J Food Sci 19:143–147CrossRef

11.

Rondini L, Peyrat-Maillard MN, Marsset-Baglieri A et al (2004) Bound ferulic acid from bran is more bioavailable than the free compound in rat. J Agric Food Chem 52:4338–4343CrossRef

12.

Aarabi A, Honarvar M, Mizani M, Faghihian H (2015) Determination of total phenolic compounds, antioxidant activity and ferulic acid in extracts of sugar beet pulp. Hacettepe J Biol Chem 43:251–257

13.

Gogoi P, Gogoi A, Rajbangshi C et al (2017) Extraction, purification and spectroscopic characterization of ferulic acid by alkaline hydrolysis from brans of Assam, India. Imp J Interdiscip Res 3:358–361

Title: Determination of (E)-ferulic acid content in the root of Angelica acutiloba: a simple chemical evaluation method for crude drug quality control
Authors: Noriko Shinjyo
Hiroyuki Fuchino
Nobuo Kawahara
Atsuyuki Hishida
Publication date: 01-06-2018
Publisher: Springer Singapore
Published in: Journal of Natural Medicines / Issue 3/2018
Print ISSN: 1340-3443
Electronic ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-018-1190-1

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Determination of (E)-ferulic acid content in the root of Angelica acutiloba: a simple chemical evaluation method for crude drug quality control

Abstract

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 3/2018

Cladosporamide A, a new protein tyrosine phosphatase 1B inhibitor, produced by an Indonesian marine sponge-derived Cladosporium sp.

Correction to: Cypripedin, a phenanthrenequinone from Dendrobium densiflorum, sensitizes non-small cell lung cancer H460 cells to cisplatin-mediated apoptosis

Berberine protects renal tubular cells against hypoxia/reoxygenation injury via the Sirt1/p53 pathway

Cellular mechanism for herbal medicine Junchoto to facilitate intestinal Cl−/water secretion that involves cAMP-dependent activation of CFTR

Scutellaria baicalensis regulates FFA metabolism to ameliorate NAFLD through the AMPK-mediated SREBP signaling pathway

Three new 5,6,7,8-tetrahydroxy-5,6,7,8-tetrahydrochromone derivatives enantiomeric to agarotetrol from agarwood