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01-03-2018 | Original Paper

Lanostane triterpenoids from Fomitopsis officinalis and their trypanocidal activity

Authors: Shinen Naranmandakh, Toshihiro Murata, Batsukh Odonbayar, Keisuke Suganuma, Javzan Batkhuu, Kenroh Sasaki

Published in: Journal of Natural Medicines | Issue 2/2018

Abstract

Fomitopsis officinalis is a medicinal fungus, known as ‘Agarikon’, and is used traditionally in the treatment of asthma and rheumatism in Mongolia. The investigation of the chemical constituents of F. officinalis led to the isolation of 4 new lanostane triterpenoids together with 4 known triterpenoids. Inhibitory activity against Trypanosoma congolense, which causes fatal diseases in animals including livestock, was estimated for the isolated compounds. Compounds 2–5 and 8 exhibited moderate inhibition activities with IC₅₀ values ranging from 7.0−27.1 µM.

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Title: Lanostane triterpenoids from Fomitopsis officinalis and their trypanocidal activity
Authors: Shinen Naranmandakh
Toshihiro Murata
Batsukh Odonbayar
Keisuke Suganuma
Javzan Batkhuu
Kenroh Sasaki
Publication date: 01-03-2018
Publisher: Springer Singapore
Published in: Journal of Natural Medicines / Issue 2/2018
Print ISSN: 1340-3443
Electronic ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-018-1182-1

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Lanostane triterpenoids from Fomitopsis officinalis and their trypanocidal activity

Abstract

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Abstract

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