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Published in:

01-03-2018 | Original Paper

Anti-oral common pathogenic bacterial active acetylenic acids from Thesium chinense Turcz

Authors: Chang Liu, Xiao-Tian Li, Rong-Rong Cheng, Zhu-Zhen Han, Li Yang, Zhong-Chen Song, Zheng-Tao Wang

Published in: Journal of Natural Medicines | Issue 2/2018

Abstract

Discovery of agents for oral infectious diseases is always encouraged in natural products chemistry. A bioassay-guided isolation led to the isolation of two new acetylenic acids (1, 2) along with seven known ones (3–9) from the ethanol extract of Thesium chinense Turcz, a commonly used oral anti-bacterial and anti-inflammatory herb. Their structures were elucidated on the basis of spectroscopic and chemical evidence. Exocarpic acid (3) demonstrated the most promising activity against three tested oral pathogenic bacterial strains, Porphyromonas gingivalis, Fusobacterium nucleatum, and Streptococcus mutans, with minimum inhibitory concentration values of 0.86, 3.43, and 13.70 μg/mL, respectively. Compounds 1, 2, 4, 5 and 7 also showed potential activities against periodontal bacteria (P. gingivalis, F. nucleatum).

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Title: Anti-oral common pathogenic bacterial active acetylenic acids from Thesium chinense Turcz
Authors: Chang Liu
Xiao-Tian Li
Rong-Rong Cheng
Zhu-Zhen Han
Li Yang
Zhong-Chen Song
Zheng-Tao Wang
Publication date: 01-03-2018
Publisher: Springer Singapore
Published in: Journal of Natural Medicines / Issue 2/2018
Print ISSN: 1340-3443
Electronic ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-018-1180-3

At a glance: The STEP trials

Springer Medicine

Anti-oral common pathogenic bacterial active acetylenic acids from Thesium chinense Turcz

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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