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01-03-2018 | Original Paper

New diterpenes from Nigella damascena seeds and their antiviral activities against herpes simplex virus type-1

Authors: Keiko Ogawa, Seikou Nakamura, Kohei Hosokawa, Hanako Ishimaru, Natsuki Saito, Kaori Ryu, Masahiro Fujimuro, Souichi Nakashima, Hisashi Matsuda

Published in: Journal of Natural Medicines | Issue 2/2018

Abstract

Nigella species are rich source of dolabellane diterpenes. During our study of Nigella species, new dolabellane diterpenes, damasterpenes V–VIII were isolated. The structural determination of new compounds damasterpenes V–VIII is described with consideration of their absolute configurations. The antiviral activities against herpes simplex virus type-1 of the isolated compounds and their derivatives are also evaluated. Damasterpene V (inhibition 35.0%) and 2-phenylacetyl 13-benzoyl damasterpenol (32.0%) showed significant antiviral activity at 10 μM.

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Title: New diterpenes from Nigella damascena seeds and their antiviral activities against herpes simplex virus type-1
Authors: Keiko Ogawa
Seikou Nakamura
Kohei Hosokawa
Hanako Ishimaru
Natsuki Saito
Kaori Ryu
Masahiro Fujimuro
Souichi Nakashima
Hisashi Matsuda
Publication date: 01-03-2018
Publisher: Springer Singapore
Published in: Journal of Natural Medicines / Issue 2/2018
Print ISSN: 1340-3443
Electronic ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-017-1166-6

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

New diterpenes from Nigella damascena seeds and their antiviral activities against herpes simplex virus type-1

Abstract

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

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