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Journal of Natural Medicines
Published in: Journal of Natural Medicines 1/2018

01-01-2018 | Note

Two new cytotoxic stilbenoid dimers isolated from Cajanus cajan

Authors: Nenling Zhang, Xiangchun Shen, Xiaofei Jiang, Jiazhong Cai, Xiaoling Shen, Yingjie Hu, Samuel X. Qiu

Published in: Journal of Natural Medicines | Issue 1/2018

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Abstract

Two new stilbenoid dimers, cajanstilbenoids A (1) and B (2), were isolated from the leaves of Cajanus cajan. Planar structures of these compounds were verified by NMR (1D and 2D) and high-resolution electrospray ionization mass spectroscopy (HR-ESI–MS). Absolute configurations were assigned by comparing experimental and calculated electronic CD values. The cytotoxicity of 1 and 2 against human hepatoma (HepG2), human breast adenocarcinoma (MCF-7), and human lung cancer (A549) cells were evaluated in vitro. Compound 1 showed strong cytotoxicity against all the tested cell lines (IC50 values: 2.14–2.56 µM), whereas compound 2 showed strong toxicity only against HepG2 (IC50 value: 5.99 µM) and A549 cells (IC50 value: 6.18 µM).
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Metadata
Title
Two new cytotoxic stilbenoid dimers isolated from Cajanus cajan
Authors
Nenling Zhang
Xiangchun Shen
Xiaofei Jiang
Jiazhong Cai
Xiaoling Shen
Yingjie Hu
Samuel X. Qiu
Publication date
01-01-2018
Publisher
Springer Singapore
Published in
Journal of Natural Medicines / Issue 1/2018
Print ISSN: 1340-3443
Electronic ISSN: 1861-0293
DOI
https://doi.org/10.1007/s11418-017-1138-x

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