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01-10-2017 | Original Paper

Triterpenoid saponins from Polaskia chichipe Backbg. and their inhibitory or promotional effects on the melanogenesis of B16 melanoma cells

Authors: Koji Fujihara, Kunio Takahashi, Kiyotaka Koyama, Kaoru Kinoshita

Published in: Journal of Natural Medicines | Issue 4/2017

Abstract

Five new oleanane-type saponins 1–5 together with a known saponin 6 and a steroidal glycoside 7 were isolated from Polaskia chichipe Backbg., and their structures were determined from their 1D and 2D NMR and HRFABMS spectral data. The six isolated saponins 1–6 were tested for their effects on the melanogenesis of B16 melanoma 4A5 cells. Compound 1 exerted an inhibitory effect at 100 μM whereas compound 3 promoted melanogenesis at the same concentration, even though these two compounds contain the same aglycon structure. The dose-dependent activities of compounds 1 and 3 on melanin synthesis were investigated.

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Title: Triterpenoid saponins from Polaskia chichipe Backbg. and their inhibitory or promotional effects on the melanogenesis of B16 melanoma cells
Authors: Koji Fujihara
Kunio Takahashi
Kiyotaka Koyama
Kaoru Kinoshita
Publication date: 01-10-2017
Publisher: Springer Singapore
Published in: Journal of Natural Medicines / Issue 4/2017
Print ISSN: 1340-3443
Electronic ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-017-1082-9

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Triterpenoid saponins from Polaskia chichipe Backbg. and their inhibitory or promotional effects on the melanogenesis of B16 melanoma cells

Abstract

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Abstract

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