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Journal of Natural Medicines
Published in: Journal of Natural Medicines 1/2017

01-01-2017 | Original Paper

Nobiletin improves emotional and novelty recognition memory but not spatial referential memory

Authors: Jiyun Kang, Jung-Won Shin, Yoo-rim Kim, Kelley M. Swanberg, Yooseung Kim, Jae Ryong Bae, Young Ki Kim, Jinwon Lee, Soo-yeon Kim, Nak-Won Sohn, Sungho Maeng

Published in: Journal of Natural Medicines | Issue 1/2017

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Abstract

How to maintain and enhance cognitive functions for both aged and young populations is a highly interesting subject. But candidate memory-enhancing reagents are tested almost exclusively on lesioned or aged animals. Also, there is insufficient information on the type of memory these reagents can improve. Working memory, located in the prefrontal cortex, manages short-term sensory information, but, by gaining significant relevance, this information is converted to long-term memory by hippocampal formation and/or amygdala, followed by tagging with space–time or emotional cues, respectively. Nobiletin is a product of citrus peel known for cognitive-enhancing effects in various pharmacological and neurodegenerative disease models, yet, it is not well studied in non-lesioned animals and the type of memory that nobiletin can improve remains unclear. In this study, 8-week-old male mice were tested using behavioral measurements for working, spatial referential, emotional and visual recognition memory after daily administration of nobiletin. While nobiletin did not induce any change of spontaneous activity in the open field test, freezing by fear conditioning and novel object recognition increased. However, the effectiveness of spatial navigation in the Y-maze and Morris water maze was not improved. These results mean that nobiletin can specifically improve memories of emotionally salient information associated with fear and novelty, but not of spatial information without emotional saliency. Accordingly, the use of nobiletin on normal subjects as a memory enhancer would be more effective on emotional types but may have limited value for the improvement of episodic memories.
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Metadata
Title
Nobiletin improves emotional and novelty recognition memory but not spatial referential memory
Authors
Jiyun Kang
Jung-Won Shin
Yoo-rim Kim
Kelley M. Swanberg
Yooseung Kim
Jae Ryong Bae
Young Ki Kim
Jinwon Lee
Soo-yeon Kim
Nak-Won Sohn
Sungho Maeng
Publication date
01-01-2017
Publisher
Springer Japan
Published in
Journal of Natural Medicines / Issue 1/2017
Print ISSN: 1340-3443
Electronic ISSN: 1861-0293
DOI
https://doi.org/10.1007/s11418-016-1047-4

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