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Journal of Natural Medicines
Published in: Journal of Natural Medicines 3/2016

01-07-2016 | Note

Lucidumol C, a new cytotoxic lanostanoid triterpene from Ganoderma lingzhi against human cancer cells

Authors: Yhiya M. Amen, Qinchang Zhu, Hai-Bang Tran, Mohamed S. Afifi, Ahmed F. Halim, Ahmed Ashour, Amira Mira, Kuniyoshi Shimizu

Published in: Journal of Natural Medicines | Issue 3/2016

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Abstract

A new oxygenated lanostane-type triterpene, named lucidumol C, together with six known compounds, was isolated from the chloroform extract of the fruiting bodies of Ganoderma lingzhi. Structures were established based on extensive spectroscopic and chemical studies. Potential cytotoxic activities of the isolated compounds were evaluated against human colorectal carcinoma (HCT-116, Caco-2), human liver carcinoma (HepG2), and human cervical carcinoma (HeLa) cell lines using WST-1 reagent. Selectivity was evaluated using normal human fibroblast cells (TIG-1 and HF19). Among the compounds, lucidumol C showed potent selective cytotoxicity against HCT-116 cells with an IC50 value of 7.86 ± 4.56 µM and selectivity index (SI) >10 with remarkable cytotoxic activities against Caco-2, HepG2 and HeLa cell lines.
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Metadata
Title
Lucidumol C, a new cytotoxic lanostanoid triterpene from Ganoderma lingzhi against human cancer cells
Authors
Yhiya M. Amen
Qinchang Zhu
Hai-Bang Tran
Mohamed S. Afifi
Ahmed F. Halim
Ahmed Ashour
Amira Mira
Kuniyoshi Shimizu
Publication date
01-07-2016
Publisher
Springer Japan
Published in
Journal of Natural Medicines / Issue 3/2016
Print ISSN: 1340-3443
Electronic ISSN: 1861-0293
DOI
https://doi.org/10.1007/s11418-016-0976-2

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