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01-01-2016 | Note

ent-Atisane diterpenoids from Euphorbia fischeriana inhibit mammosphere formation in MCF-7 cells

Authors: Xinzhu Kuang, Wei Li, Yuichiro Kanno, Naoya Yamashita, Kiyomitsu Nemoto, Yoshihisa Asada, Kazuo Koike

Published in: Journal of Natural Medicines | Issue 1/2016

Abstract

The discovery of new drugs that target cancer stem cells (CSCs) is a critical approach to overcome the major difficulties of the metastasis, chemotherapeutic resistance and recurrence for successful cancer therapy. Chemical investigation of the roots of Euphorbia fischeriana resulted in the isolation of eight ent-atisane diterpenoids (1–8), including two new compounds: 19-O-β-D-glucopyranosyl-ent-atis-16-ene-3,14-dione (7) and 19-O-(6-galloyl)-β-D-glucopyranosyl-ent-atis-16-ene-3,14-dione (8). The structures were elucidated on extensive spectroscopic analyses, as well as chemical transformations. ent-3β-Hydroxyatis-16-ene-2,14-dione (5), 7 and its aglycon, ent-19-hydroxy-atis-16-ene-3,14-dione (7a), showed significant inhibitory activity on mammosphere formation in human breast cancer MCF-7 cells at a final concentration of 10 μM.

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Title: ent-Atisane diterpenoids from Euphorbia fischeriana inhibit mammosphere formation in MCF-7 cells
Authors: Xinzhu Kuang
Wei Li
Yuichiro Kanno
Naoya Yamashita
Kiyomitsu Nemoto
Yoshihisa Asada
Kazuo Koike
Publication date: 01-01-2016
Publisher: Springer Japan
Published in: Journal of Natural Medicines / Issue 1/2016
Print ISSN: 1340-3443
Electronic ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-015-0940-6

At a glance: The STEP trials

Springer Medicine

ent-Atisane diterpenoids from Euphorbia fischeriana inhibit mammosphere formation in MCF-7 cells

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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