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01-07-2014 | Original Paper

3,4-seco-24-homo-28-nor-Cycloartane and drimane-type sesquiterpenes and their lactams from the EtOAc-soluble fraction of a leaf extract of Cinnamosma fragrans and their biological activity

Authors: Yuya Nomoto, Liva Harinantenaina, Sachiko Sugimoto, Katsuyoshi Matsunami, Hideaki Otsuka

Published in: Journal of Natural Medicines | Issue 3/2014

Abstract

From the EtOAc-soluble fraction of a MeOH extract of leaves of Cinnamosma fragrans, seven new compounds, including 3,4-seco-24-homo-28-nor-cycloartane, drimane-type sesquiterpenes and their lactams, and two known compounds were isolated. Their structures were elucidated by extensive analyses of spectroscopic data. The cytotoxicity, anti-multidrug resistance activity, and anti-Leishmania activity of a cycloartane derivative and drimane-type sesquiterpene derivatives were assayed. The cycloartane derivative showed strong cytotoxicity, and some drimanes and drimane lactam showed moderate anti-multidrug resistance and anti-Leishmania activity.

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Title: 3,4-seco-24-homo-28-nor-Cycloartane and drimane-type sesquiterpenes and their lactams from the EtOAc-soluble fraction of a leaf extract of Cinnamosma fragrans and their biological activity
Authors: Yuya Nomoto
Liva Harinantenaina
Sachiko Sugimoto
Katsuyoshi Matsunami
Hideaki Otsuka
Publication date: 01-07-2014
Publisher: Springer Japan
Published in: Journal of Natural Medicines / Issue 3/2014
Print ISSN: 1340-3443
Electronic ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-014-0828-x

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3,4-seco-24-homo-28-nor-Cycloartane and drimane-type sesquiterpenes and their lactams from the EtOAc-soluble fraction of a leaf extract of Cinnamosma fragrans and their biological activity

Abstract

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Abstract

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