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01-07-2013 | Original Paper

Gastroprotective activity of the ethanolic extract and hexane phase of Combretum duarteanum Cambess. (Combretaceae)

Authors: Gedson Rodrigues de Morais Lima, Camila de Albuquerque Montenegro, Heloina de Sousa Falcão, Neyres Zínea Taveira de Jesus, Analúcia Guedes Silveira Cabral, Isis Fernandes Gomes, Maria de Fátima Agra, Josean Fechine Tavares, Leônia Maria Batista

Published in: Journal of Natural Medicines | Issue 3/2013

Abstract

Combretum duarteanum Cambess. is found in South America, particularly in Bolivia, Paraguay, and Brazil. In Paraiba state (Brazil), the species usually occurs in the Caatinga biome. It is popularly known as mofumbo, cipiúba, or cipaúba. This work aims to evaluate the gastroprotective activity and the cytoprotective mechanisms of the ethanolic extract (Cd-EtOHE) and hexane phase (Cd-HexP) obtained from the leaves of C. duarteanum. Doses at 62.5, 125, 250, and 500 mg/kg of Cd-EtOHE and Cd-HexP were tested in models of gastric ulcers induced by HCl/ethanol, absolute ethanol, stress, non-steroidal anti-inflammatory drugs, and pylorus ligation in male rats or mice. Cd-EtOHE and Cd-HexP significantly reduced gastric injuries induced in all models. Cd-EtOHE and Cd-HexP did not alter gastric juice parameters such as pH, [H⁺], or volume after pylorus ligation. Cytoprotective mechanisms of Cd-EtOHE and Cd-HexP in relation to mucus, nitric oxide (NO), and sulfhydryl (SH) groups were evaluated. Neither product increased the mucus, and they both showed dependence on NO and SH groups to prevent gastric ulcer. Both Cd-EtOHE and Cd-HexP demonstrated gastroprotective activity.

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Title: Gastroprotective activity of the ethanolic extract and hexane phase of Combretum duarteanum Cambess. (Combretaceae)
Authors: Gedson Rodrigues de Morais Lima
Camila de Albuquerque Montenegro
Heloina de Sousa Falcão
Neyres Zínea Taveira de Jesus
Analúcia Guedes Silveira Cabral
Isis Fernandes Gomes
Maria de Fátima Agra
Josean Fechine Tavares
Leônia Maria Batista
Publication date: 01-07-2013
Publisher: Springer Japan
Published in: Journal of Natural Medicines / Issue 3/2013
Print ISSN: 1340-3443
Electronic ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-012-0706-3

At a glance: The STEP trials

Springer Medicine

Gastroprotective activity of the ethanolic extract and hexane phase of Combretum duarteanum Cambess. (Combretaceae)

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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