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Journal of Natural Medicines
Published in: Journal of Natural Medicines 2/2012

01-04-2012 | Note

Curcuminoid analogs inhibit nitric oxide production from LPS-activated microglial cells

Authors: Jiraporn Tocharus, Sataporn Jamsuwan, Chainarong Tocharus, Chatchawan Changtam, Apichart Suksamrarn

Published in: Journal of Natural Medicines | Issue 2/2012

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Abstract

The chemically modified analogs, the demethylated analogs 4–6, the tetrahydro analogs 7–9 and the hexahydro analogs 10–12, of curcumin (1), demethoxycurcumin (2) and bisdemethoxycurcumin (3) were evaluated for their inhibitory activity on lipopolysaccharide activated nitric oxide (NO) production in HAPI microglial cells. Di-O-demethylcurcumin (5) and O-demethyldemethoxycurcumin (6) are the two most potent compounds that inhibited NO production. The analogs 5 and 6 were twofold and almost twofold more active than the parent curcuminoids 1 and 2, respectively. Moreover, the mRNA expression level of inducible NO synthase was inhibited by these two compounds. The strong neuroprotective activity of analogs 5 and 6 provide potential alternative compounds to be developed as therapeutics for neurological disorders associated with activated microglia.
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Metadata
Title
Curcuminoid analogs inhibit nitric oxide production from LPS-activated microglial cells
Authors
Jiraporn Tocharus
Sataporn Jamsuwan
Chainarong Tocharus
Chatchawan Changtam
Apichart Suksamrarn
Publication date
01-04-2012
Publisher
Springer Japan
Published in
Journal of Natural Medicines / Issue 2/2012
Print ISSN: 1340-3443
Electronic ISSN: 1861-0293
DOI
https://doi.org/10.1007/s11418-011-0599-6

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