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Apoptosis of HL-60 leukemia cells induced by carbazole alkaloids isolated from Murraya euchrestifolia

Authors: Chihiro Ito, Masataka Itoigawa, Keisuke Nakao, Tomiyasu Murata, Norio Kaneda, Hiroshi Furukawa

Published in: Journal of Natural Medicines | Issue 2/2012

Abstract

We carried out primary screening of 13 carbazole alkaloids isolated from the plant species Murraya euchrestifolia (Rutaceae) on cell growth inhibition of the human leukemia cell line HL-60. Among them, murrayafoline-A (1) and murrayazolinine (7) exhibited significant growth suppression due to apoptosis mediated by the activation of the caspase-9/caspase-3 pathway.

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Title: Apoptosis of HL-60 leukemia cells induced by carbazole alkaloids isolated from Murraya euchrestifolia
Authors: Chihiro Ito
Masataka Itoigawa
Keisuke Nakao
Tomiyasu Murata
Norio Kaneda
Hiroshi Furukawa
Publication date: 01-04-2012
Publisher: Springer Japan
Published in: Journal of Natural Medicines / Issue 2/2012
Print ISSN: 1340-3443
Electronic ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-011-0584-0

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Apoptosis of HL-60 leukemia cells induced by carbazole alkaloids isolated from Murraya euchrestifolia

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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