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01-04-2010 | Original Paper

Phenolic compounds from Cryptocarya konishii: their cytotoxic and tyrosine kinase inhibitory properties

Authors: Fera Kurniadewi, Lia D. Juliawaty, Yana M. Syah, Sjamsul A. Achmad, Euis H. Hakim, Kiyotaka Koyama, Kaoru Kinoshita, Kunio Takahashi

Published in: Journal of Natural Medicines | Issue 2/2010

Abstract

Two chalcone derivatives, 2′-hydroxychalcone (1) and desmethylinfectocaryone (2), together with five known phenolic compounds infectocaryone (3), cryptocaryone (4), kurzichalcolactone A (5), pinocembrin (6) and trans-N-feruloyltyramine (7), were isolated from the methanol extract of the wood of Cryptocarya konishii. The structures of the new compounds were determined based on the analysis of spectroscopic data, including UV, IR, 1D and 2D NMR, and mass spectra. Evaluation of the cytotoxic and tyrosine kinase inhibitory activities of compounds 1–7 showed that compounds 2–4 strongly inhibited the growth of murine leukemia P-388 cells, whereas compound 4 significantly inhibited the enzyme.

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Title: Phenolic compounds from Cryptocarya konishii: their cytotoxic and tyrosine kinase inhibitory properties
Authors: Fera Kurniadewi
Lia D. Juliawaty
Yana M. Syah
Sjamsul A. Achmad
Euis H. Hakim
Kiyotaka Koyama
Kaoru Kinoshita
Kunio Takahashi
Publication date: 01-04-2010
Publisher: Springer Japan
Published in: Journal of Natural Medicines / Issue 2/2010
Print ISSN: 1340-3443
Electronic ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-009-0368-y

At a glance: The STEP trials

Springer Medicine

Phenolic compounds from Cryptocarya konishii: their cytotoxic and tyrosine kinase inhibitory properties

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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