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Published in:

01-10-2009 | Original Paper

Antihyperlipidaemic activity of swertiamarin, a secoiridoid glycoside in poloxamer-407-induced hyperlipidaemic rats

Authors: Hitesh Vaidya, Mandapati Rajani, Vasudevan Sudarsanam, Harish Padh, Ramesh Goyal

Published in: Journal of Natural Medicines | Issue 4/2009

Abstract

We have investigated antihyperlipidaemic effect of swertiamarin (50 mg/kg, oral once) isolated from the perennial herb Enicostemma littorale Blume in poloxamer 407 (P-407)-induced hyperlipidaemic rats. Rats were made hyperlipidaemic by intraperitoneal administration of P-407 (400 mg/kg). Serum lipid levels such as total cholesterol, triglycerides and low-density lipoprotein cholesterol increased significantly (P < 0.001) compared with normal control rats. All these changes were significantly prevented in the rats treated with swertiamarin. Serum high-density lipoprotein (HDL) cholesterol was found to be reduced in the P-407 control rats. However, administration of swertiamarin significantly (P < 0.01) increased HDL levels and it showed a significant lipid-lowering effect, as well as a high antiatherogenic potential. Overall swertiamarin is an effective lipid-lowering lead compound and can be useful for preventing atherosclerosis.

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Title: Antihyperlipidaemic activity of swertiamarin, a secoiridoid glycoside in poloxamer-407-induced hyperlipidaemic rats
Authors: Hitesh Vaidya
Mandapati Rajani
Vasudevan Sudarsanam
Harish Padh
Ramesh Goyal
Publication date: 01-10-2009
Publisher: Springer Japan
Published in: Journal of Natural Medicines / Issue 4/2009
Print ISSN: 1340-3443
Electronic ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-009-0350-8

At a glance: The STEP trials

Springer Medicine

Antihyperlipidaemic activity of swertiamarin, a secoiridoid glycoside in poloxamer-407-induced hyperlipidaemic rats

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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