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01-04-2008 | Original Paper

Antinociceptive, anti-inflammatory, and antipyretic properties of an aqueous extract of Dicranopteris linearis leaves in experimental animal models

Authors: Zainul Amiruddin Zakaria, Zuleen Delina Fasya Abdul Ghani, Raden Nur Suraya Raden Mohd. Nor, Hanan Kumar Gopalan, Mohd. Roslan Sulaiman, Abdul Manan Mat Jais, Muhammad Nazrul Somchit, Arifah Abdul Kader, Johari Ripin

Published in: Journal of Natural Medicines | Issue 2/2008

Abstract

This study was performed out to establish the antinociceptive, anti-inflammatory, and antipyretic properties of an aqueous extract of Dicranopteris linearis leaves in experimental animals. The antinociceptive activity was measured using the abdominal constriction, hot plate, and formalin tests. The anti-inflammatory and antipyretic activities were measured using the carrageenan-induced paw edema and brewer’s yeast-induced pyrexia tests, respectively. The extract, obtained after 72 h soaking of the air-dried leaves in distilled water and then prepared in the doses of 13.2, 66.0, 132.0, and 660.0 mg/kg, was administered subcutaneously 30 min before subjecting the animals to the assays mentioned above. Generally, the extract, at all doses used, was found to have significant (P < 0.05) concentration-independent antinociceptive, anti-inflammatory, and anti-pyretic activity. In conclusion, the aqueous extract of D. linearis has antinociceptive, anti-inflammatory, and antipyretic activity, supporting previous claims of its traditional use by the Malays to treat various ailments, particularly fever.

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Title: Antinociceptive, anti-inflammatory, and antipyretic properties of an aqueous extract of Dicranopteris linearis leaves in experimental animal models
Authors: Zainul Amiruddin Zakaria
Zuleen Delina Fasya Abdul Ghani
Raden Nur Suraya Raden Mohd. Nor
Hanan Kumar Gopalan
Mohd. Roslan Sulaiman
Abdul Manan Mat Jais
Muhammad Nazrul Somchit
Arifah Abdul Kader
Johari Ripin
Publication date: 01-04-2008
Publisher: Springer Japan
Published in: Journal of Natural Medicines / Issue 2/2008
Print ISSN: 1340-3443
Electronic ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-007-0224-x

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Antinociceptive, anti-inflammatory, and antipyretic properties of an aqueous extract of Dicranopteris linearis leaves in experimental animal models

Abstract

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Springer Medicine

Abstract

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