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Sport Sciences for Health
Published in: Sport Sciences for Health 1/2019

01-04-2019 | Original Article

Positive effect of moderate-intensity aerobic activity on pentylenetetrazol-induced epileptic behaviors in pregnant mice and cognitive performance in adult male offspring

Authors: Ayoob Sabaghi, Ali Heyrani, Amir Kiani, Namdar Yousofvand

Published in: Sport Sciences for Health | Issue 1/2019

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Abstract

Purpose

Epilepsy is one of the common neurological disorders. It has been reported that physical activity can be a complementary therapy to treat seizures. Therefore, the present study was designed to investigate the effect of aerobic training on pentylenetetrazol (PTZ)-induced seizure in pregnant mice.

Methods

The kindled female mice were divided into eight groups including (1) pregnant mice (PC) treated with PTZ without physical training (PT), (2) PC treated with PTZ with aerobic training (AT), (3) PC treated with normal saline (NS), (4) PC without any injection in pregnancy, (5) non-PC treated with PTZ without PT, (6) non-PC treated with PTZ with AT, (7) non-PC treated with NS and (8) non-PC without any injection. The seizure activity was measured for half an hour after PTZ injection and anxiety activity was assessed 2 h after PTZ injection. Also, at postnatal day 94, cognitive performance at male offspring of the groups was evaluated.

Results

The results showed that aerobic training reduced seizure severity and restored seizure-induced anxiety in pregnant and non-pregnant mice to control levels. It was also observed that aerobic activity during pregnancy would restore the cognitive function of the offspring in pregnant mice treated with PTZ to the male offspring’s level in control group.

Conclusion

Generally, the results of this study showed that moderate-intensity AT is an appropriate treatment strategy for reducing the severity of seizure, seizure-induced anxiety and also prevents cognitive impairment due to seizure induction during pregnancy in the male offspring.
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Metadata
Title
Positive effect of moderate-intensity aerobic activity on pentylenetetrazol-induced epileptic behaviors in pregnant mice and cognitive performance in adult male offspring
Authors
Ayoob Sabaghi
Ali Heyrani
Amir Kiani
Namdar Yousofvand
Publication date
01-04-2019
Publisher
Springer Milan
Published in
Sport Sciences for Health / Issue 1/2019
Print ISSN: 1824-7490
Electronic ISSN: 1825-1234
DOI
https://doi.org/10.1007/s11332-018-0485-7

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