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Sport Sciences for Health
Published in: Sport Sciences for Health 1/2019

01-04-2019 | Original Article

Long-term effects of sprint interval training on expression of cardiac genes involved in energy efficiency

Authors: Hossein TaheriChadorneshin, Fatemeh Rostamkhani, Hossein Shirvani

Published in: Sport Sciences for Health | Issue 1/2019

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Abstract

Purpose

The real mechanisms of intensive exercise training-induced energy efficiency have not yet been well examined. Therefore, the aim of the present study was to investigate the effects of sprint interval training (SIT) on gene expression of uncoupling proteins (UCPs) and endothelial nitric oxide synthase (eNOS).

Methods

For this purpose, 16 Albino Wistar rats (250–300 g) were randomly divided into equal groups of control and sprint training. The animals run on treadmill for 10 weeks, 5 days per week at intensity corresponding to 90–95% maximal oxygen consumption. The gene expression of UCP2, UCP3 and eNOS was analyzed by RT-PCR method in hearts. The data were analyzed by independent samples T test at P < 0.05 level.

Results

Sprint interval training significantly decreased mRNA expression of UCP2 (t14 = 4.818, P = 0.001) and UCP3 (t14 = 4.620, P = 0.001) in cardiac muscle of rats. In contrast, mRNA expression of eNOS in cardiac muscle significantly increased following sprint interval training (t14 = 7.967, P = 0.001).

Conclusion

This study elucidates that SIT through reduction in gene expression of uncoupling proteins can improve energy efficiency. But, more studies are needed to confirm this hypothesis.

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Metadata
Title
Long-term effects of sprint interval training on expression of cardiac genes involved in energy efficiency
Authors
Hossein TaheriChadorneshin
Fatemeh Rostamkhani
Hossein Shirvani
Publication date
01-04-2019
Publisher
Springer Milan
Published in
Sport Sciences for Health / Issue 1/2019
Print ISSN: 1824-7490
Electronic ISSN: 1825-1234
DOI
https://doi.org/10.1007/s11332-018-0480-z

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