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01-12-2018 | Original Article

Nitric oxide and blood pressure responses to short-term resistance training in adults with and without type-2 diabetes: a randomized controlled trial

Authors: Marcelo Magalhães Sales, Caio Victor de Sousa, Hugo Alexandre de Paula Santana, Daisy Motta-Santos, Lucas Pinheiro Barbosa, Patrick Anderson Santos, Taia Maria Berto Rezende, Rodrigo Alberto Vieira Browne, Rosângela Vieira de Andrade, Herbert Gustavo Simões

Published in: Sport Sciences for Health | Issue 3/2018

Abstract

Background

Type-2 diabetes (T2D) is associated with endothelial dysfunction, increase in sympathetic tone and several cardiovascular disorders, such as systemic arterial hypertension and coronary artery disease.

Aims

To determine the effects of resistance training (RT) on the responses of nitric oxide (NO) and blood pressure (BP) in individuals with T2D and their controls peers.

Methods

Randomized controlled trial in which T2D patients and non-diabetic individuals (ND) performed 8 weeks of RT. Participants were 22 women and 12 men (age 62.3 ± 2.5 years) that were randomly allocated into four groups: T2D training (n = 9), ND training (n = 10), T2D control (n = 8), and ND control (n = 7). NO and BP were measured before and after the whole intervention.

Results

There were no significant differences in nitrite concentrations between and within groups, with values varying between 1.22 ± 0.15 and 1.45 ± 0.13 Log µM. The T2D and ND experimental groups decreased systolic blood pressure (SBP) by 8.1 and 1.4 mmHg, respectively. However, the control groups showed elevation of SBP (3.6 mmHg for T2D and 4.1 mmHg for ND). Although none of these changes were significant (p > 0.05). In addition, T2D subjects who did not undergo the training increased diastolic blood pressure (p = 0.030) and mean arterial pressure (p = 0.054).

Conclusions

Eight weeks of RT does not increase NO bioavailability, and in turn, does not reduce BP in T2D patients—though it prevented its increase.

Trial registration

ensaiosclinicos.gov.br (ID: RBR-4d39z9).

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Title: Nitric oxide and blood pressure responses to short-term resistance training in adults with and without type-2 diabetes: a randomized controlled trial
Authors: Marcelo Magalhães Sales
Caio Victor de Sousa
Hugo Alexandre de Paula Santana
Daisy Motta-Santos
Lucas Pinheiro Barbosa
Patrick Anderson Santos
Taia Maria Berto Rezende
Rodrigo Alberto Vieira Browne
Rosângela Vieira de Andrade
Herbert Gustavo Simões
Publication date: 01-12-2018
Publisher: Springer Milan
Published in: Sport Sciences for Health / Issue 3/2018
Print ISSN: 1824-7490
Electronic ISSN: 1825-1234
DOI: https://doi.org/10.1007/s11332-018-0468-8

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Nitric oxide and blood pressure responses to short-term resistance training in adults with and without type-2 diabetes: a randomized controlled trial

Abstract

Background

Aims

Methods

Results

Conclusions

Trial registration

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Aims

Methods

Results

Conclusions

Trial registration

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