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18-01-2023 | Sleep Apnea | Sleep Breathing Physiology and Disorders • Original Article

Serum uric acid is related to left ventricular geometry and function in patients with obstructive sleep apnea

Authors: Wen Shui, Jian Wang, Tong Cui, Caihong Kang, Zhenxia Zhang

Published in: Sleep and Breathing | Issue 5/2023

Abstract

Introduction

Serum uric acid (SUA) is an oxidative stress-related biomarker of cardiovascular risk. We sought to discover whether or not SUA was related to left ventricular geometry (LVG) and function among individuals with obstructive sleep apnea (OSA).

Methods

Patients with OSA and healthy controls were assessed for clinical features, echocardiography, polysomnography, and blood biochemical data. Patients with OSA were divided into four groups: normal geometry (NG), concentric remodeling (CR), eccentric hypertrophy (EH), and concentric hypertrophy (CH). Correlations of SUA with left ventricular (LV) structure and function were examined through Pearson correlation analysis. The risk variables of LVG were investigated using a multivariate logistic regression model.

Results

Compared to controls, patients with OSA had greater SUA levels. The eccentric hypertrophy (EH) and concentric hypertrophy (CH) groups showed substantially greater SUA levels than the normal geometry (NG) and concentric remodeling (CR) groups (p < 0.05). SUA correlated positively with left ventricular mass index (LVMI) and relative wall thickness (RWT) but negatively with the E/A ratio, according to the Pearson correlation analysis. SUA independently affected EH (OR = 1.021, 95%CI = 1.015–1.028, p < 0.001) and CH (OR = 1.034, 95%CI = 1.025–1.043, p < 0.001) in patients with OSA by the multivariate logistic regression model.

Conclusions

Patients with OSA had elevated levels of SUA, which were seen to be closely linked with abnormal LVG and function. The findings suggest that SUA may raise the risk of LV structural and functional impairment in patients with OSA.

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Title: Serum uric acid is related to left ventricular geometry and function in patients with obstructive sleep apnea
Authors: Wen Shui
Jian Wang
Tong Cui
Caihong Kang
Zhenxia Zhang
Publication date: 18-01-2023
Publisher: Springer International Publishing
Keywords: Sleep Apnea
Echocardiography
Polysomnography
Echocardiography
Published in: Sleep and Breathing / Issue 5/2023
Print ISSN: 1520-9512
Electronic ISSN: 1522-1709
DOI: https://doi.org/10.1007/s11325-022-02771-3

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Abstract

Introduction

Methods

Results

Conclusions

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