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Molecular Imaging and Biology
Published in: Molecular Imaging and Biology 3/2018

01-06-2018 | Review Article

Imaging of Nanoparticle Distribution to Assess Treatments That Alter Delivery

Authors: Stephanie J. Blocker, Anthony F. Shields

Published in: Molecular Imaging and Biology | Issue 3/2018

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Abstract

Molecular imaging is a vital tool to non-invasively measure nanoparticle delivery to solid tumors. Despite the myriad of nanoparticles studied for cancer, successful applications of nanoparticles in humans is limited by inconsistent and ineffective delivery. Successful nanoparticle delivery in preclinical models is often attributed to enhanced permeability and retention (EPR)—a set of conditions that is heterogeneous and transient in patients. Thus, researchers are evaluating therapeutic strategies to modify nanoparticle delivery, particularly treatments which have demonstrated effects on EPR conditions. Imaging nanoparticle distribution provides a means to measure the effects of therapeutic intervention on nanoparticle delivery to solid tumors. This review focuses on the utility of imaging to measure treatment-induced changes in nanoparticle delivery to tumors and provides preclinical examples studying a broad range of therapeutic interventions.
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Metadata
Title
Imaging of Nanoparticle Distribution to Assess Treatments That Alter Delivery
Authors
Stephanie J. Blocker
Anthony F. Shields
Publication date
01-06-2018
Publisher
Springer International Publishing
Published in
Molecular Imaging and Biology / Issue 3/2018
Print ISSN: 1536-1632
Electronic ISSN: 1860-2002
DOI
https://doi.org/10.1007/s11307-017-1142-2

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