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Molecular Imaging and Biology
Published in: Molecular Imaging and Biology 5/2018

01-10-2018 | Review Article

Standardization of Small Animal Imaging—Current Status and Future Prospects

Authors: Julia G. Mannheim, Firat Kara, Janine Doorduin, Kerstin Fuchs, Gerald Reischl, Sayuan Liang, Marleen Verhoye, Felix Gremse, Laura Mezzanotte, Marc C. Huisman

Published in: Molecular Imaging and Biology | Issue 5/2018

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Abstract

The benefit of small animal imaging is directly linked to the validity and reliability of the collected data. If the data (regardless of the modality used) are not reproducible and/or reliable, then the outcome of the data is rather questionable. Therefore, standardization of the use of small animal imaging equipment, as well as of animal handling in general, is of paramount importance. In a recent paper, guidance for efficient small animal imaging quality control was offered and discussed, among others, the use of phantoms in setting up a quality control program (Osborne et al. 2016). The same phantoms can be used to standardize image quality parameters for multi-center studies or multi-scanners within center studies. In animal experiments, the additional complexity due to animal handling needs to be addressed to ensure standardized imaging procedures. In this review, we will address the current status of standardization in preclinical imaging, as well as potential benefits from increased levels of standardization.
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Metadata
Title
Standardization of Small Animal Imaging—Current Status and Future Prospects
Authors
Julia G. Mannheim
Firat Kara
Janine Doorduin
Kerstin Fuchs
Gerald Reischl
Sayuan Liang
Marleen Verhoye
Felix Gremse
Laura Mezzanotte
Marc C. Huisman
Publication date
01-10-2018
Publisher
Springer International Publishing
Published in
Molecular Imaging and Biology / Issue 5/2018
Print ISSN: 1536-1632
Electronic ISSN: 1860-2002
DOI
https://doi.org/10.1007/s11307-017-1126-2

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