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Molecular Imaging and Biology
Published in: Molecular Imaging and Biology 3/2015

01-06-2015 | Research Article

NEMA NU 4-Optimized Reconstructions for Therapy Assessment in Cancer Research with the Inveon Small Animal PET/CT System

Authors: Charline Lasnon, Audrey Emmanuelle Dugue, Mélanie Briand, Cécile Blanc-Fournier, Soizic Dutoit, Marie-hélène Louis, Nicolas Aide

Published in: Molecular Imaging and Biology | Issue 3/2015

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Abstract

Purpose

We compared conventional filtered back-projection (FBP), two-dimensional-ordered subsets expectation maximization (OSEM) and maximum a posteriori (MAP) NEMA NU 4-optimized reconstructions for therapy assessment.

Procedures

Varying reconstruction settings were used to determine the parameters for optimal image quality with two NEMA NU 4 phantom acquisitions. Subsequently, data from two experiments in which nude rats bearing subcutaneous tumors had received a dual PI3K/mTOR inhibitor were reconstructed with the NEMA NU 4-optimized parameters. Mann–Whitney tests were used to compare mean standardized uptake value (SUVmean) variations among groups.

Results

All NEMA NU 4-optimized reconstructions showed the same 2-deoxy-2-[18F]fluoro-d-glucose ([18F]FDG) kinetic patterns and detected a significant difference in SUVmean relative to day 0 between controls and treated groups for all time points with comparable p values.

Conclusion

In the framework of therapy assessment in rats bearing subcutaneous tumors, all algorithms available on the Inveon system performed equally.
Appendix
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Metadata
Title
NEMA NU 4-Optimized Reconstructions for Therapy Assessment in Cancer Research with the Inveon Small Animal PET/CT System
Authors
Charline Lasnon
Audrey Emmanuelle Dugue
Mélanie Briand
Cécile Blanc-Fournier
Soizic Dutoit
Marie-hélène Louis
Nicolas Aide
Publication date
01-06-2015
Publisher
Springer US
Published in
Molecular Imaging and Biology / Issue 3/2015
Print ISSN: 1536-1632
Electronic ISSN: 1860-2002
DOI
https://doi.org/10.1007/s11307-014-0805-5

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