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Molecular Imaging and Biology
Published in: Molecular Imaging and Biology 5/2010

01-10-2010 | Research Article

A Study on the Prognostic Evaluation of Carbon Ion Radiotherapy for Head and Neck Adenocarcinoma with C-11 Methionine PET

Authors: Mitsuhiko Hasebe, Kyosan Yoshikawa, Seiya Ohashi, Sachiko Toubaru, Koji Kawaguchi, Junichi Sato, Junetsu Mizoe, Hirohiko Tsujii

Published in: Molecular Imaging and Biology | Issue 5/2010

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Abstract

Purpose

Carbon ion radiotherapy (CIRT) has been developed, and a phase I/II CIRT trial has been conducted in patients with adenocarcinoma in the head and neck region. We evaluated whether the l-methyl [11C]-methionine (MET) uptake could be an early predictor for local recurrence, metastasis, and the prognosis in patients with adenocarcinoma in the head and neck region.

Methods

Twenty-six patients were prospectively studied by MET-positron emission tomography (PET) before and about 1 month after CIRT. The tumor MET uptake was measured with the semiquantitative tumor to normal tissue ratio (TNR). The tumor TNR and relevant clinical parameters were then evaluated by both univariate and multivariate analyses.

Results

The average TNRs before and after the treatment were 6.2 (±2.2) and 3.9 (±1.7), respectively, and significant differences were observed between them. In a univariate analysis, both local recurrence and metastasis were observed more frequently in the group with a higher TNR before and after the treatment than a lower TNR, and the prognosis was also poor. The cut-off values were 9.3, 4.9, and 5.1 before the treatment and 4.9, 4.2, and 4.3 after the treatment, respectively. In the rate of TNR changes before and after the treatment, metastasis was observed more frequently in the group with lower rates of change, and the prognosis was poor. The cut-off values for metastasis and prognosis determination were 18.0% and 16.9%, respectively. In a multivariate analysis, significant differences were observed for all relationships except for the relationship between the TNR before the treatment and local recurrence. Significant differences were observed for metastasis and prognosis in the rate of TNR changes before and after the treatment.

Conclusions

The determination of treatment effectiveness using TNR in CIRT for head and neck adenocarcinoma is an independent factor for predicting local recurrence, the incidence of metastasis, and the prognosis. MET-PET is therefore considered to be useful for determining the treatment effectiveness in patients with head and neck adenocarcinoma undergoing CIRT.
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Metadata
Title
A Study on the Prognostic Evaluation of Carbon Ion Radiotherapy for Head and Neck Adenocarcinoma with C-11 Methionine PET
Authors
Mitsuhiko Hasebe
Kyosan Yoshikawa
Seiya Ohashi
Sachiko Toubaru
Koji Kawaguchi
Junichi Sato
Junetsu Mizoe
Hirohiko Tsujii
Publication date
01-10-2010
Publisher
Springer-Verlag
Published in
Molecular Imaging and Biology / Issue 5/2010
Print ISSN: 1536-1632
Electronic ISSN: 1860-2002
DOI
https://doi.org/10.1007/s11307-010-0318-9

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