Skip to main content
Top
Published in: Quality of Life Research 2/2021

Open Access 01-02-2021 | Care | Review

Quality of life of cancer patients at palliative care units in developing countries: systematic review of the published literature

Authors: Dwi Gayatri, Ljupcho Efremov, Eva Johanna Kantelhardt, Rafael Mikolajczyk

Published in: Quality of Life Research | Issue 2/2021

Login to get access

Abstract

Purpose

This systematic review aims to summarize factors that influence the quality of life (QOL) of advanced cancer patients in palliative care (PC) in developing countries. Understanding this context in developing countries milieu is necessary; however, this outcome is rarely reported.

Methods

Following the PRISMA guidelines, the electronic databases MEDLINE, Embase, CINAHL, and Web of Science were systematically searched using the search terms: QOL, cancer, PC, and names of all developing countries. Studies with less than ten subjects, qualitative or pilot studies, reviews, conference abstracts, and that reported validation of QOL questionnaires were excluded.

Results

Fifty-five studies from 15 developing countries in the African (n = 5), Latin America and the Caribbean (n = 10), and Asian (n = 40) region were included in the narrative synthesis. 65.4% were cross-sectional, 27.3% were cohort studies, 7.3% were RCTs or quasi-experimental studies. Around 30 QOL factors were studied with 20 different types of QOL instruments. Advanced cancer patients who were older, married/ever married, participated in additional care within PC, used complementary and alternative medicine (CAM), and practiced spirituality/religiosity showed higher QOL score. Low educational level and high depression were associated with a lower QOL.

Conclusion

Various factors affect QOL among cancer patients in PC. Patients valued the use of CAMs; however, the quality and safety aspects should be properly addressed. Important factors that influenced the QOL score were social and spiritual support. While there is a general need to develop PC strategies further, recognizing patients’ needs should be prioritized in national cancer programs.
Appendix
Available only for authorised users
Literature
3.
go back to reference Aboshaiqah, A., Al-Saedi, T. S., Abu-Al-Ruyhaylah, M. M., Aloufi, A. A., Alharbi, M. O., Alharbi, S. S., et al. (2016). Quality of life and satisfaction with care among palliative cancer patients in Saudi Arabia. Palliative & Supportive Care, 14(6), 621–627.CrossRef Aboshaiqah, A., Al-Saedi, T. S., Abu-Al-Ruyhaylah, M. M., Aloufi, A. A., Alharbi, M. O., Alharbi, S. S., et al. (2016). Quality of life and satisfaction with care among palliative cancer patients in Saudi Arabia. Palliative & Supportive Care, 14(6), 621–627.CrossRef
14.
go back to reference Loney, P. L., Chambers, L. W., Bennett, K. J., Roberts, J. G., & Stratford, P. W. (1998). Critical appraisal of the health research literature: Prevalence or incidence of a health problem. Chronic Dis Can, 19(4), 170–176.PubMed Loney, P. L., Chambers, L. W., Bennett, K. J., Roberts, J. G., & Stratford, P. W. (1998). Critical appraisal of the health research literature: Prevalence or incidence of a health problem. Chronic Dis Can, 19(4), 170–176.PubMed
18.
go back to reference Bulbul, Y., Ozlu, T., Arinc, S., Ozyurek, B. A., Gunbatar, H., Senturk, A., et al. (2017). Assessment of palliative care in lung cancer in Turkey. Medical Principles & Practice, 26(1), 50–56.CrossRef Bulbul, Y., Ozlu, T., Arinc, S., Ozyurek, B. A., Gunbatar, H., Senturk, A., et al. (2017). Assessment of palliative care in lung cancer in Turkey. Medical Principles & Practice, 26(1), 50–56.CrossRef
21.
go back to reference Chan, K. Y., Chan, M. L., Yau, T. C. C., Li, C. W., Cheng, H. W., & Sham, M. K. (2012). Quality of life for Hong Kong Chinese patients with advanced gynecological cancers in the palliative phase of care: A cross-sectional study. Journal of Palliative Care, 28(4), 259–266.CrossRef Chan, K. Y., Chan, M. L., Yau, T. C. C., Li, C. W., Cheng, H. W., & Sham, M. K. (2012). Quality of life for Hong Kong Chinese patients with advanced gynecological cancers in the palliative phase of care: A cross-sectional study. Journal of Palliative Care, 28(4), 259–266.CrossRef
22.
go back to reference Kim, K. U. (2014). Measurement of quality of life in patients with end-stage cancer [Multicenter Study]. Cancer Nursing, 37(1), 44–49.CrossRef Kim, K. U. (2014). Measurement of quality of life in patients with end-stage cancer [Multicenter Study]. Cancer Nursing, 37(1), 44–49.CrossRef
23.
go back to reference Kristanti, M. S., Setiyarini, S., & Effendy, C. (2017). Enhancing the quality of life for palliative care cancer patients in Indonesia through family caregivers: A pilot study of basic skills training. BMC Palliative Care, 16(1), 4.CrossRef Kristanti, M. S., Setiyarini, S., & Effendy, C. (2017). Enhancing the quality of life for palliative care cancer patients in Indonesia through family caregivers: A pilot study of basic skills training. BMC Palliative Care, 16(1), 4.CrossRef
24.
go back to reference Yan, S. (2006). Quality of life of patients with terminal cancer receiving palliative home care. The Journal of Palliative Care, 22(4), 261–266.CrossRef Yan, S. (2006). Quality of life of patients with terminal cancer receiving palliative home care. The Journal of Palliative Care, 22(4), 261–266.CrossRef
25.
go back to reference Chang, J. A., & Lin, C. C. (2009). A longitudinal study of the role of patient-reported outcomes on survival prediction of palliative cancer inpatients in Taiwan [Research Support, Non-U.S. Gov't]. Supportive Care in Cancer, 17(10), 1285–1294.CrossRef Chang, J. A., & Lin, C. C. (2009). A longitudinal study of the role of patient-reported outcomes on survival prediction of palliative cancer inpatients in Taiwan [Research Support, Non-U.S. Gov't]. Supportive Care in Cancer, 17(10), 1285–1294.CrossRef
26.
go back to reference Cui, J., Fang, F., Shen, F., Song, L., Zhou, L., Ma, X., et al. (2014). Quality of life in patients with advanced cancer at the end of life as measured by the McGill quality of life questionnaire: A survey in China. Journal of Pain and Symptom Management, 48(5), 893–902.CrossRef Cui, J., Fang, F., Shen, F., Song, L., Zhou, L., Ma, X., et al. (2014). Quality of life in patients with advanced cancer at the end of life as measured by the McGill quality of life questionnaire: A survey in China. Journal of Pain and Symptom Management, 48(5), 893–902.CrossRef
28.
go back to reference Aamir, S., Zuraida, N., Loh, E. C., & Beng, T. S. (2012). Correlation between anxiety, depression, family functioning and quality of life, in palliative care cancer patients. International Journal of Medicine and Medical Sciences, 2(10), 204–208. Aamir, S., Zuraida, N., Loh, E. C., & Beng, T. S. (2012). Correlation between anxiety, depression, family functioning and quality of life, in palliative care cancer patients. International Journal of Medicine and Medical Sciences, 2(10), 204–208.
30.
go back to reference Mehta, S., Sharma, S. C., Kapoor, R., Kochhar, R., & Mehta, V. (2008). Quality of life assessment with different radiotherapy schedules in palliative management of advanced carcinoma esophagus: A prospective randomized study. Indian Journal of Palliative Care, 14(2), 90–96.CrossRef Mehta, S., Sharma, S. C., Kapoor, R., Kochhar, R., & Mehta, V. (2008). Quality of life assessment with different radiotherapy schedules in palliative management of advanced carcinoma esophagus: A prospective randomized study. Indian Journal of Palliative Care, 14(2), 90–96.CrossRef
34.
go back to reference Lee, M. K., Lee, W. J., Do, Y. R., Lee, K. S., Jung, K. H., Heo, D. S., et al. (2015). Changes in health-related quality of life and quality of care among terminally ill cancer patients and survival prediction: Multicenter prospective cohort study. Palliative & Supportive Care, 13(4), 1103–1111.CrossRef Lee, M. K., Lee, W. J., Do, Y. R., Lee, K. S., Jung, K. H., Heo, D. S., et al. (2015). Changes in health-related quality of life and quality of care among terminally ill cancer patients and survival prediction: Multicenter prospective cohort study. Palliative & Supportive Care, 13(4), 1103–1111.CrossRef
36.
go back to reference Mendez, L. C., Raman, S., Wan, B. A., da Silva, J. L. P., Moraes, F. Y., Lima, K. M. L. B., et al. (2017). Quality of life in responders after palliative radiation therapy for painful bone metastases using EORTC QLQ-C30 and EORTC QLQ-BM22: Results of a Brazilian cohort. Annals of Palliative Medicine, 6(Supplement 1), S65–S70.CrossRef Mendez, L. C., Raman, S., Wan, B. A., da Silva, J. L. P., Moraes, F. Y., Lima, K. M. L. B., et al. (2017). Quality of life in responders after palliative radiation therapy for painful bone metastases using EORTC QLQ-C30 and EORTC QLQ-BM22: Results of a Brazilian cohort. Annals of Palliative Medicine, 6(Supplement 1), S65–S70.CrossRef
40.
go back to reference Wang, Y., Shen, J., & Xu, Y. (2011). Symptoms and quality of life of advanced cancer patients at home: A cross-sectional study in Shanghai [Research Support, Non-U.S. Gov't]. China. Supportive Care in Cancer, 19(6), 789–797.CrossRef Wang, Y., Shen, J., & Xu, Y. (2011). Symptoms and quality of life of advanced cancer patients at home: A cross-sectional study in Shanghai [Research Support, Non-U.S. Gov't]. China. Supportive Care in Cancer, 19(6), 789–797.CrossRef
41.
go back to reference Alfano, A. C., Paiva, C. E., Rugno, F. C., da Silva, R. H., & Paiva, B. S. (2014). Biologically based therapies are commonly self-prescribed by Brazilian women for the treatment of advanced breast cancer or its symptoms. Supportive Care in Cancer, 22(5), 1303–1311.CrossRef Alfano, A. C., Paiva, C. E., Rugno, F. C., da Silva, R. H., & Paiva, B. S. (2014). Biologically based therapies are commonly self-prescribed by Brazilian women for the treatment of advanced breast cancer or its symptoms. Supportive Care in Cancer, 22(5), 1303–1311.CrossRef
42.
go back to reference Chaiviboontham, S. (2015). Factors predicting the effectiveness of palliative care in patients with advanced cancer [Research Support, Non-U.S. Gov't]. Palliative & Supportive Care, 13(4), 997–1003.CrossRef Chaiviboontham, S. (2015). Factors predicting the effectiveness of palliative care in patients with advanced cancer [Research Support, Non-U.S. Gov't]. Palliative & Supportive Care, 13(4), 997–1003.CrossRef
44.
go back to reference Pokpalagon, P., Hanucharurnkul, S., McCorkle, R., Tongprateep, T., Patoomwan, A., & Viwatwongkasem, C. (2012). Comparison of care strategies and quality of life of advanced cancer patients from four different palliative care settings. Pacific Rim International Journal of Nursing Research, 16(4), 326–342. Pokpalagon, P., Hanucharurnkul, S., McCorkle, R., Tongprateep, T., Patoomwan, A., & Viwatwongkasem, C. (2012). Comparison of care strategies and quality of life of advanced cancer patients from four different palliative care settings. Pacific Rim International Journal of Nursing Research, 16(4), 326–342.
45.
46.
go back to reference Yoon, S. J., Suh, S. Y., Kim, S. H., Park, J., Kim, Y. J., Kang, B., et al. (2018). Factors associated with religiosity and spiritual well-being in advanced cancer inpatients of palliative care units in a multireligious country [Conference Abstract]. Palliative Medicine, 32(Supplement 1), 150. Yoon, S. J., Suh, S. Y., Kim, S. H., Park, J., Kim, Y. J., Kang, B., et al. (2018). Factors associated with religiosity and spiritual well-being in advanced cancer inpatients of palliative care units in a multireligious country [Conference Abstract]. Palliative Medicine, 32(Supplement 1), 150.
48.
go back to reference Fan, X., Huang, H., Luo, Q., Zhou, J., Tan, G., & Yong, N. (2011). Quality of life in Chinese home-based advanced cancer patients: Does awareness of cancer diagnosis matter? [Research Support, Non-U.S. Gov't]. Journal of Palliative Medicine, 14(10), 1104–1108.CrossRef Fan, X., Huang, H., Luo, Q., Zhou, J., Tan, G., & Yong, N. (2011). Quality of life in Chinese home-based advanced cancer patients: Does awareness of cancer diagnosis matter? [Research Support, Non-U.S. Gov't]. Journal of Palliative Medicine, 14(10), 1104–1108.CrossRef
51.
go back to reference Tang, S. T., Chang, W. C., Chen, J. S., Chou, W. C., Hsieh, C. H., & Chen, C. H. (2016). Associations of prognostic awareness/acceptance with psychological distress, existential suffering, and quality of life in terminally ill cancer patients' last year of life [Research Support, Non-U.S. Gov't]. Psycho-Oncology, 25(4), 455–462.CrossRef Tang, S. T., Chang, W. C., Chen, J. S., Chou, W. C., Hsieh, C. H., & Chen, C. H. (2016). Associations of prognostic awareness/acceptance with psychological distress, existential suffering, and quality of life in terminally ill cancer patients' last year of life [Research Support, Non-U.S. Gov't]. Psycho-Oncology, 25(4), 455–462.CrossRef
52.
go back to reference Deng, D., Lin, W., & Law, F. (2015). The study on evaluation and improvement of quality of life in patients with advanced cancer by China's hospice program [Comparative Study, Multicenter Study]. American Journal of Hospice & Palliative Medicine, 32(4), 365–371.CrossRef Deng, D., Lin, W., & Law, F. (2015). The study on evaluation and improvement of quality of life in patients with advanced cancer by China's hospice program [Comparative Study, Multicenter Study]. American Journal of Hospice & Palliative Medicine, 32(4), 365–371.CrossRef
53.
54.
go back to reference Lakew, S., Musema, H., Shimeles, T., & Challinor, J. (2015). Assessment of knowledge, accessibility and utilization of palliative care services among adult cancer patients at Tikur Anbesa Specialized Hospital, Addis Ababa, Ethiopia, 2014: A cross-sectional institution based study. BMC Research Notes, 8, 657.CrossRef Lakew, S., Musema, H., Shimeles, T., & Challinor, J. (2015). Assessment of knowledge, accessibility and utilization of palliative care services among adult cancer patients at Tikur Anbesa Specialized Hospital, Addis Ababa, Ethiopia, 2014: A cross-sectional institution based study. BMC Research Notes, 8, 657.CrossRef
55.
go back to reference Ogoncho, I. M., Omuga, B. O., Wakasiaka, S., & Muiva, M. (2016). Quality of life among gynaecological cancer patients receiving palliative care in Kenya: A cross-sectional study. African Journal of Midwifery & Women's Health, 10(1), 15-18. 10.12968/ajmw.2016.10.1.15 Ogoncho, I. M., Omuga, B. O., Wakasiaka, S., & Muiva, M. (2016). Quality of life among gynaecological cancer patients receiving palliative care in Kenya: A cross-sectional study. African Journal of Midwifery & Women's Health, 10(1), 15-18. 10.12968/ajmw.2016.10.1.15
58.
go back to reference Wang, Y. C., & Lin, C. C. (2016). Spiritual Well-being May Reduce the Negative Impacts of Cancer Symptoms on the Quality of Life and the Desire for Hastened Death in Terminally Ill Cancer Patients. Cancer Nursing, 39(4), E43–50.CrossRef Wang, Y. C., & Lin, C. C. (2016). Spiritual Well-being May Reduce the Negative Impacts of Cancer Symptoms on the Quality of Life and the Desire for Hastened Death in Terminally Ill Cancer Patients. Cancer Nursing, 39(4), E43–50.CrossRef
63.
go back to reference Regional Office for the Western Pacific. (2012). The Regional Strategy for Traditional Medicine in the Western Pacific (2011–2020). Manila: WHO Regional Office for the Western Pacific. Regional Office for the Western Pacific. (2012). The Regional Strategy for Traditional Medicine in the Western Pacific (2011–2020). Manila: WHO Regional Office for the Western Pacific.
64.
go back to reference World Health Organization. (2013). WHO Traditional Medicine Strategy: 2014–2023. WHO Library Cataloguing-in-Publication Data. World Health Organization. (2013). WHO Traditional Medicine Strategy: 2014–2023. WHO Library Cataloguing-in-Publication Data.
67.
go back to reference Koenig, H., King, D., & Carson, V. B. (2012). Handbook of religion and health. New York: Oxford University Press. Koenig, H., King, D., & Carson, V. B. (2012). Handbook of religion and health. New York: Oxford University Press.
70.
go back to reference Puchalski, C. M. (1999). Touching the spirit: The essence of healing. Spiritual Life, 45, 154–159. Puchalski, C. M. (1999). Touching the spirit: The essence of healing. Spiritual Life, 45, 154–159.
73.
78.
go back to reference Bates, M. J., & Mijoya, A. (2015). A review of patients with advanced cervical cancer presenting to palliative care services at Queen Elizabeth Central Hospital in Blantyre, Malawi. Malawi Medical Journal, 27(3), 93–95.CrossRef Bates, M. J., & Mijoya, A. (2015). A review of patients with advanced cervical cancer presenting to palliative care services at Queen Elizabeth Central Hospital in Blantyre, Malawi. Malawi Medical Journal, 27(3), 93–95.CrossRef
79.
go back to reference Kamau, R. K., Osoti, A. O., & Njuguna, E. M. (2007). Effect of diagnosis and treatment of inoperable cervical cancer on quality of life among women receiving radiotherapy at Kenyatta National Hospital. East African Medical Journal, 84(1), 24–30.CrossRef Kamau, R. K., Osoti, A. O., & Njuguna, E. M. (2007). Effect of diagnosis and treatment of inoperable cervical cancer on quality of life among women receiving radiotherapy at Kenyatta National Hospital. East African Medical Journal, 84(1), 24–30.CrossRef
82.
go back to reference Abu-Saad Huijer, H., Doumit, M., Abboud, S., & Dimassi, H. (2012). Quality of palliative care. Perspective of Lebanese patients with cancer. [Research Support, Non-U.S. Gov't]. Journal Medical Libanais—Lebanese Medical Journal, 60(2), 91–98. Abu-Saad Huijer, H., Doumit, M., Abboud, S., & Dimassi, H. (2012). Quality of palliative care. Perspective of Lebanese patients with cancer. [Research Support, Non-U.S. Gov't]. Journal Medical Libanais—Lebanese Medical Journal, 60(2), 91–98.
84.
go back to reference Ezat, S. W. P., Fuad, I., Hayati, Y., Zafar, A., & Kiyah, G. A. W. (2014). Observational study on patient’s satisfactions and Quality of Life (QoL) among cancer patients receiving treatment with palliative care intent in a tertiary hospital in Malaysia. Asian Pacific Journal of Cancer Prevention, 15(2), 695–701.CrossRef Ezat, S. W. P., Fuad, I., Hayati, Y., Zafar, A., & Kiyah, G. A. W. (2014). Observational study on patient’s satisfactions and Quality of Life (QoL) among cancer patients receiving treatment with palliative care intent in a tertiary hospital in Malaysia. Asian Pacific Journal of Cancer Prevention, 15(2), 695–701.CrossRef
85.
go back to reference Lee, Y. J., Suh, S. Y., Choi, Y. S., Shim, J. Y., Seo, A. R., Choi, S. E., et al. (2014). EORTC QLQ-C15-PAL quality of life score as a prognostic indicator of survival in patients with far advanced cancer. Supportive Care in Cancer, 22(7), 1941–1948.CrossRef Lee, Y. J., Suh, S. Y., Choi, Y. S., Shim, J. Y., Seo, A. R., Choi, S. E., et al. (2014). EORTC QLQ-C15-PAL quality of life score as a prognostic indicator of survival in patients with far advanced cancer. Supportive Care in Cancer, 22(7), 1941–1948.CrossRef
86.
go back to reference Li, Q., Lin, Y., Qiu, Y., Gao, B., & Xu, Y. (2014). The assessment of health-related quality of life and related factors in Chinese elderly patients undergoing chemotherapy for advanced cancer: A cross-sectional study [Clinical Trial, Research Support, Non-U.S. Gov't]. European Journal of Oncology Nursing, 18(4), 425–435.CrossRef Li, Q., Lin, Y., Qiu, Y., Gao, B., & Xu, Y. (2014). The assessment of health-related quality of life and related factors in Chinese elderly patients undergoing chemotherapy for advanced cancer: A cross-sectional study [Clinical Trial, Research Support, Non-U.S. Gov't]. European Journal of Oncology Nursing, 18(4), 425–435.CrossRef
87.
go back to reference Shahmoradi, N., Kandiah, M., & Loh, S. P. (2012). Quality of life and functional status in patients with advanced cancer admitted to hospice home care in Malaysia: A cross-sectional study. European Journal of Cancer Care, 21(5), 661–666.CrossRef Shahmoradi, N., Kandiah, M., & Loh, S. P. (2012). Quality of life and functional status in patients with advanced cancer admitted to hospice home care in Malaysia: A cross-sectional study. European Journal of Cancer Care, 21(5), 661–666.CrossRef
Metadata
Title
Quality of life of cancer patients at palliative care units in developing countries: systematic review of the published literature
Authors
Dwi Gayatri
Ljupcho Efremov
Eva Johanna Kantelhardt
Rafael Mikolajczyk
Publication date
01-02-2021
Publisher
Springer International Publishing
Keyword
Care
Published in
Quality of Life Research / Issue 2/2021
Print ISSN: 0962-9343
Electronic ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-020-02633-z

Other articles of this Issue 2/2021

Quality of Life Research 2/2021 Go to the issue