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Quality of Life Research
Published in: Quality of Life Research 11/2020

Open Access 01-11-2020 | Fatigue

Longitudinal associations of light-intensity physical activity with quality of life, functioning and fatigue after colorectal cancer

Authors: E. H. van Roekel, J. Duchâteau, M. J. L. Bours, L. van Delden, J. J. L. Breedveld-Peters, J. L. Koole, M. Kenkhuis, P. A. van den Brandt, R. L. Jansen, I. Kant, V. Lima Passos, K. Meijer, S. O. Breukink, M. L. G. Janssen-Heijnen, E. Keulen, M. P. Weijenberg

Published in: Quality of Life Research | Issue 11/2020

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Abstract

Purpose

Evidence from cross-sectional studies suggests that higher levels of light-intensity physical activity (LPA) are associated with better health-related quality of life (HRQoL) in colorectal cancer (CRC) survivors. However, these associations have not been investigated in longitudinal studies that provide the opportunity to analyse how within-individual changes in LPA affect HRQoL. We investigated longitudinal associations of LPA with HRQoL outcomes in CRC survivors, from 6 weeks to 2 years post-treatment.

Methods

Data were used of a prospective cohort study among 325 stage I–III CRC survivors (67% men, mean age: 67 years), recruited between 2012 and 2016. Validated questionnaires were used to assess hours/week of LPA (SQUASH) and HRQoL outcomes (EORTC QLQ-C30, Checklist Individual Strength) at 6 weeks, and 6, 12 and 24 months post-treatment. We applied linear mixed regression to analyse longitudinal confounder-adjusted associations of LPA with HRQoL.

Results

We observed statistically significant longitudinal associations between more LPA and better global quality of life and physical, role and social functioning, and less fatigue over time. Intra-individual analysis showed that within-person increases in LPA (per 8 h/week) were related to improved HRQoL, including better global quality of life (β = 1.67, 95% CI 0.71; 2.63; total range scale: 0–100) and less fatigue (β = − 1.22, 95% CI − 2.37; − 0.07; scale: 20–140). Stratified analyses indicated stronger associations among participants below the median of moderate-to-vigorous physical activity (MVPA) at diagnosis.

Conclusion

Higher levels of LPA were longitudinally associated with better HRQoL and less fatigue in CRC survivors up to two years post-treatment. Further prospective studies using accelerometer data are necessary to inform development of interventions targeting LPA.
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Metadata
Title
Longitudinal associations of light-intensity physical activity with quality of life, functioning and fatigue after colorectal cancer
Authors
E. H. van Roekel
J. Duchâteau
M. J. L. Bours
L. van Delden
J. J. L. Breedveld-Peters
J. L. Koole
M. Kenkhuis
P. A. van den Brandt
R. L. Jansen
I. Kant
V. Lima Passos
K. Meijer
S. O. Breukink
M. L. G. Janssen-Heijnen
E. Keulen
M. P. Weijenberg
Publication date
01-11-2020
Publisher
Springer International Publishing
Published in
Quality of Life Research / Issue 11/2020
Print ISSN: 0962-9343
Electronic ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-020-02566-7

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