Published in:
Open Access 01-11-2012
Comparing higher order models for the EORTC QLQ-C30
Published in: Quality of Life Research | Issue 9/2012
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Purpose
To investigate the statistical fit of alternative higher order models for summarizing the health-related quality of life profile generated by the EORTC QLQ-C30 questionnaire.
Methods
A 50% random sample was drawn from a dataset of more than 9,000 pre-treatment QLQ-C30 v 3.0 questionnaires completed by cancer patients from 48 countries, differing in primary tumor site and disease stage. Building on a “standard” 14-dimensional QLQ-C30 model, confirmatory factor analysis was used to compare 6 higher order models, including a 1-dimensional (1D) model, a 2D “symptom burden and function” model, two 2D “mental/physical” models, and two models with a “formative” (or “causal”) formulation of “symptom burden,” and “function.”
Results
All of the models considered had at least an “adequate” fit to the data: the less restricted the model, the better the fit. The RMSEA fit indices for the various models ranged from 0.042 to 0.061, CFI’s 0.90–0.96, and TLI’s from 0.96 to 0.98. All chi-square tests were significant. One of the Physical/Mental models had fit indices superior to the other models considered.
Conclusions
The Physical/Mental health model had the best fit of the higher order models considered, and enjoys empirical and theoretical support in comparable instruments and applications.