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Quality of Life Research
Published in: Quality of Life Research 2/2009

Open Access 01-03-2009

Validation of modified forms of the PedsQL generic core scales and cancer module scales for adolescents and young adults (AYA) with cancer or a blood disorder

Authors: Jane E. Ewing, Madeleine T. King, Narelle F. Smith

Published in: Quality of Life Research | Issue 2/2009

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Abstract

Purpose

To validate two health-related quality of life (HRQOL) measures, the PedsQL Generic Core and Cancer Module adolescent forms (13–18 years), after modification for 16–25-year-old adolescents and young adults (AYA) with cancer or a blood disorder.

Methods

AYA patients and nominated proxies were recruited from three Sydney hospitals. Modified forms were administered by telephone or in clinics/wards. Analyses included correlations, factor analysis, and analysis of variance of known-groups (defined by the Memorial Symptom Assessment Scale).

Results

Eighty-eight patients and 79 proxies completed questionnaires. Factor structures consistent with those of the unmodified forms confirmed construct validity. Cronbach’s alpha ranged 0.81–0.98. Inter-scale correlations were as hypothesized, confirming discriminant validity. Statistically significant differences between groups with mild, moderate, and severe symptoms (P < 0.05) confirmed clinical validity.

Conclusion

These modified forms provide reliable and valid measures of HRQOL in AYA with cancer or a blood disorder, suitable for clinical trials, research, and practice.
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Metadata
Title
Validation of modified forms of the PedsQL generic core scales and cancer module scales for adolescents and young adults (AYA) with cancer or a blood disorder
Authors
Jane E. Ewing
Madeleine T. King
Narelle F. Smith
Publication date
01-03-2009
Publisher
Springer Netherlands
Published in
Quality of Life Research / Issue 2/2009
Print ISSN: 0962-9343
Electronic ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-008-9424-4

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