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Psychiatric Quarterly
Published in: Psychiatric Quarterly 1/2012

01-03-2012 | Original Article

Neurologic and Psychiatric Manifestations of Celiac Disease and Gluten Sensitivity

Authors: Jessica R. Jackson, William W. Eaton, Nicola G. Cascella, Alessio Fasano, Deanna L. Kelly

Published in: Psychiatric Quarterly | Issue 1/2012

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Abstract

Celiac Disease (CD) is an immune-mediated disease dependent on gluten (a protein present in wheat, rye or barley) that occurs in about 1% of the population and is generally characterized by gastrointestinal complaints. More recently the understanding and knowledge of gluten sensitivity (GS), has emerged as an illness distinct from celiac disease with an estimated prevalence 6 times that of CD. Gluten sensitive people do not have villous atrophy or antibodies that are present in celiac disease, but rather they can test positive for antibodies to gliadin. Both CD and GS may present with a variety of neurologic and psychiatric co-morbidities, however, extraintestinal symptoms may be the prime presentation in those with GS. However, gluten sensitivity remains undertreated and underrecognized as a contributing factor to psychiatric and neurologic manifestiations. This review focuses on neurologic and psychiatric manifestations implicated with gluten sensitivity, reviews the emergence of gluten sensitivity distinct from celiac disease, and summarizes the potential mechanisms related to this immune reaction.
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Metadata
Title
Neurologic and Psychiatric Manifestations of Celiac Disease and Gluten Sensitivity
Authors
Jessica R. Jackson
William W. Eaton
Nicola G. Cascella
Alessio Fasano
Deanna L. Kelly
Publication date
01-03-2012
Publisher
Springer US
Published in
Psychiatric Quarterly / Issue 1/2012
Print ISSN: 0033-2720
Electronic ISSN: 1573-6709
DOI
https://doi.org/10.1007/s11126-011-9186-y

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