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Published in: Neuropsychology Review 3/2009

01-09-2009 | Review

Cognitive Remediation in Schizophrenia

Authors: Alice Medalia, Jimmy Choi

Published in: Neuropsychology Review | Issue 3/2009

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Abstract

Cognitive deficits are routinely evident in schizophrenia, and are of sufficient magnitude to influence functional outcomes in work, social functioning and illness management. Cognitive remediation is an evidenced-based non-pharmacological treatment for the neurocognitive deficits seen in schizophrenia. Narrowly defined, cognitive remediation is a set of cognitive drills or compensatory interventions designed to enhance cognitive functioning, but from the vantage of the psychiatric rehabilitation field, cognitive remediation is a therapy which engages the patient in learning activities that enhance the neurocognitive skills relevant to their chosen recovery goals. Cognitive remediation programs vary in the extent to which they reflect these narrow or broader perspectives but six meta-analytic studies report moderate range effect sizes on cognitive test performance, and daily functioning. Reciprocal interactions between baseline ability level, the type of instructional techniques used, and motivation provide some explanatory power for the heterogeneity in patient response to cognitive remediation.
Literature
go back to reference Anthony, W. A., Cohen, M. R., Farkas, M. D., & Gagne, C. (2002). Psychiatric rehabilitation (2nd ed.). Boston: Boston University, Center for Psychiatric Rehabilitation. Anthony, W. A., Cohen, M. R., Farkas, M. D., & Gagne, C. (2002). Psychiatric rehabilitation (2nd ed.). Boston: Boston University, Center for Psychiatric Rehabilitation.
go back to reference Bell, M. D., Choi, J., & Lysaker, P. (2007a). Psychological interventions to improve work outcomes for people with psychiatric disabilities. Tidsskrift for Norsk Psykologforening, 44, 606–617. Bell, M. D., Choi, J., & Lysaker, P. (2007a). Psychological interventions to improve work outcomes for people with psychiatric disabilities. Tidsskrift for Norsk Psykologforening, 44, 606–617.
go back to reference Bell, M. D., Fiszdon, J. M., Greig, T., Wexler, B. W., & Bryson, G. (2007b). Neurocognitive enhancement therapy with work therapy in schizophrenia: a six month follow-up of neuropsychological performance. Journal of Rehabilitation Research and Development, 44, 761–770. doi:10.1682/JRRD.2007.02.0032.CrossRef Bell, M. D., Fiszdon, J. M., Greig, T., Wexler, B. W., & Bryson, G. (2007b). Neurocognitive enhancement therapy with work therapy in schizophrenia: a six month follow-up of neuropsychological performance. Journal of Rehabilitation Research and Development, 44, 761–770. doi:10.​1682/​JRRD.​2007.​02.​0032.CrossRef
go back to reference Berger, H. J., van Spaendonck, K. P., Horstink, M. W., Buytenhuijs, E. L., Lammers, P. W., & Cools, A. R. (1993). Cognitive shifting as a predictor of progress in social understanding in high-functioning adolescents with autism: a prospective study. Journal of Autism and Developmental Disorders, 23, 341–359. doi:10.1007/BF01046224.PubMedCrossRef Berger, H. J., van Spaendonck, K. P., Horstink, M. W., Buytenhuijs, E. L., Lammers, P. W., & Cools, A. R. (1993). Cognitive shifting as a predictor of progress in social understanding in high-functioning adolescents with autism: a prospective study. Journal of Autism and Developmental Disorders, 23, 341–359. doi:10.​1007/​BF01046224.PubMedCrossRef
go back to reference Bryson, G., & Bell, M. D. (2003). Initial and final work performance in schizophrenia: cognitive and symptom predictors. The Journal of Nervous and Mental Disease, 191, 87–92.PubMedCrossRef Bryson, G., & Bell, M. D. (2003). Initial and final work performance in schizophrenia: cognitive and symptom predictors. The Journal of Nervous and Mental Disease, 191, 87–92.PubMedCrossRef
go back to reference Choi, J., & Medalia, A. (2005). Factors associated with a positive response to cognitive remediation in a community psychiatric sample. Psychiatric Services (Washington, D.C.), 56, 602–604. doi:10.1176/appi.ps.56.5.602. Choi, J., & Medalia, A. (2005). Factors associated with a positive response to cognitive remediation in a community psychiatric sample. Psychiatric Services (Washington, D.C.), 56, 602–604. doi:10.​1176/​appi.​ps.​56.​5.​602.
go back to reference Choi, J., & Medalia, A. (2009). How to enhance intrinsic motivation within the setting of a cognitive remediation program. Schizophrenia Bulletin, 35(sup 1), 284. Choi, J., & Medalia, A. (2009). How to enhance intrinsic motivation within the setting of a cognitive remediation program. Schizophrenia Bulletin, 35(sup 1), 284.
go back to reference Choi, J., Mogami, T., & Medalia, A. (2009). Intrinsic Motivation Inventory (IMI): An adapted scale for schizophrenia research. Schizophrenia Bulletin, doi:10.1093/schbul/sbp030. Choi, J., Mogami, T., & Medalia, A. (2009). Intrinsic Motivation Inventory (IMI): An adapted scale for schizophrenia research. Schizophrenia Bulletin, doi:10.​1093/​schbul/​sbp030.
go back to reference Cicerone, K. D., Dahlberg, C., Malec, J. F., Langenbahn, D. M., Felicetti, T., Kneipp, S., et al. (2005). Evidence-based cognitive rehabilitation: updated review of the literature from 1998 through 2002. Archives of Physical Medicine and Rehabilitation, 86, 1681–1692. doi:10.1016/j.apmr.2005.03.024. see comment.PubMedCrossRef Cicerone, K. D., Dahlberg, C., Malec, J. F., Langenbahn, D. M., Felicetti, T., Kneipp, S., et al. (2005). Evidence-based cognitive rehabilitation: updated review of the literature from 1998 through 2002. Archives of Physical Medicine and Rehabilitation, 86, 1681–1692. doi:10.​1016/​j.​apmr.​2005.​03.​024. see comment.PubMedCrossRef
go back to reference Cordova, D. I., & Lepper, M. R. (1996). Intrinsic motivation and the process of learning: beneficial effects of contextualization, personalization, and choice. Journal of Educational Psychology, 88, 715–730. doi:10.1037/0022-0663.88.4.715.CrossRef Cordova, D. I., & Lepper, M. R. (1996). Intrinsic motivation and the process of learning: beneficial effects of contextualization, personalization, and choice. Journal of Educational Psychology, 88, 715–730. doi:10.​1037/​0022-0663.​88.​4.​715.CrossRef
go back to reference Cronbach, L. J., & Snow, R. E. (1977). Aptitudes and instructional methods. New York: Irvington/Naiburg. Cronbach, L. J., & Snow, R. E. (1977). Aptitudes and instructional methods. New York: Irvington/Naiburg.
go back to reference Deci, E. L., & Ryan, R. M. (2008). Facilitating optimal motivation and psychological well-being across life’s domains. Canadian Psychology/Psychologie canadienne, 49, 14–23.CrossRef Deci, E. L., & Ryan, R. M. (2008). Facilitating optimal motivation and psychological well-being across life’s domains. Canadian Psychology/Psychologie canadienne, 49, 14–23.CrossRef
go back to reference Delahunty, A., Morice, R., & Frost, B. (1993). Specific cognitive flexibility rehabilitation in schizophrenia. Psychological Medicine, 23, 221–227.PubMedCrossRef Delahunty, A., Morice, R., & Frost, B. (1993). Specific cognitive flexibility rehabilitation in schizophrenia. Psychological Medicine, 23, 221–227.PubMedCrossRef
go back to reference Dweck, C. S., Mangels, J. A., & Good, C. (2004). Motivational effects on attention, cognition, and performance. In D. Y. Dai & R. J. Sternberg (Eds.), Motivation, emotion, and cognition: Integrative perspectives on intellectual functioning and development (pp. 41–56). New Jersey: Erlbaum. Dweck, C. S., Mangels, J. A., & Good, C. (2004). Motivational effects on attention, cognition, and performance. In D. Y. Dai & R. J. Sternberg (Eds.), Motivation, emotion, and cognition: Integrative perspectives on intellectual functioning and development (pp. 41–56). New Jersey: Erlbaum.
go back to reference Elliot, A. J., & Dweck, C. S. (2005). Handbook of competence and motivation. New York: Guilford. Elliot, A. J., & Dweck, C. S. (2005). Handbook of competence and motivation. New York: Guilford.
go back to reference Gold, J. M. (2008). Is cognitive impairment in schizophrenia ready for diagnostic prime time? World Psychiatry; Official Journal of the World Psychiatric Association (WPA), 7, 32–33. Gold, J. M. (2008). Is cognitive impairment in schizophrenia ready for diagnostic prime time? World Psychiatry; Official Journal of the World Psychiatric Association (WPA), 7, 32–33.
go back to reference Green, M. F., Kern, R. S., & Heaton, R. K. (2004). Longitudinal studies of cognition and functional outcome in schizophrenia: implications for MATRICS. Schizophrenia Research, 72, 41–51.CrossRef Green, M. F., Kern, R. S., & Heaton, R. K. (2004). Longitudinal studies of cognition and functional outcome in schizophrenia: implications for MATRICS. Schizophrenia Research, 72, 41–51.CrossRef
go back to reference Green, M. F., Satz, P., Ganzell, S., & Vaclav, J. F. (1992). Wisconsin Card Sorting Test performance in schizophrenia: remediation of a stubborn deficit. The American Journal of Psychiatry, 149, 62–67.PubMed Green, M. F., Satz, P., Ganzell, S., & Vaclav, J. F. (1992). Wisconsin Card Sorting Test performance in schizophrenia: remediation of a stubborn deficit. The American Journal of Psychiatry, 149, 62–67.PubMed
go back to reference Hodge, H. R., Siciliano, D., Whithey, P., Moss, B., Judd, G., Shores, E. A., et al. (2008). A randomized controlled trial of cognitive remediation in schizophrenia. Schizophrenia Bulletin., . doi:10.1093/schbul/sbn102. Hodge, H. R., Siciliano, D., Whithey, P., Moss, B., Judd, G., Shores, E. A., et al. (2008). A randomized controlled trial of cognitive remediation in schizophrenia. Schizophrenia Bulletin., . doi:10.​1093/​schbul/​sbn102.
go back to reference Hogarty, G. E., Greenwald, D. P., & Eack, S. M. (2006). Durability and mechanism of effects of cognitive enhancement therapy. Psychiatric Services (Washington, D.C.), 57, 1751–1757. doi:10.1176/appi.ps.57.12.1751. Hogarty, G. E., Greenwald, D. P., & Eack, S. M. (2006). Durability and mechanism of effects of cognitive enhancement therapy. Psychiatric Services (Washington, D.C.), 57, 1751–1757. doi:10.​1176/​appi.​ps.​57.​12.​1751.
go back to reference Joanisse, M. F., & Seidenberg, M. S. (1999). Impairments in verb morphology after brain injury: a connectionist model. Proceedings of the National Academy of Sciences of the United States of America, 96, 7592–7597. doi:10.1073/pnas.96.13.7592.PubMedCrossRef Joanisse, M. F., & Seidenberg, M. S. (1999). Impairments in verb morphology after brain injury: a connectionist model. Proceedings of the National Academy of Sciences of the United States of America, 96, 7592–7597. doi:10.​1073/​pnas.​96.​13.​7592.PubMedCrossRef
go back to reference Kern, R. S., Wallace, C. J., Hellman, S. G., Womack, L. M., & Green, M. F. (1996). A training procedure for remediating WCST deficits in chronic psychotic patients: an adaptation of errorless learning principles. Journal of Psychiatric Research, 30, 283–294. doi:10.1016/0022-3956(96)00028-3.PubMedCrossRef Kern, R. S., Wallace, C. J., Hellman, S. G., Womack, L. M., & Green, M. F. (1996). A training procedure for remediating WCST deficits in chronic psychotic patients: an adaptation of errorless learning principles. Journal of Psychiatric Research, 30, 283–294. doi:10.​1016/​0022-3956(96)00028-3.PubMedCrossRef
go back to reference King, R., Lloyd, C., & Meehan, T. (2007). Handbook of Psychosocial Rehabilitation. Oxford: Blackwell. King, R., Lloyd, C., & Meehan, T. (2007). Handbook of Psychosocial Rehabilitation. Oxford: Blackwell.
go back to reference Kurtz, M. M., Moberg, P. J., Gur, R. C., & Gur, R. E. (2001). Approaches to cognitive remediation of neuropsychological deficits in schizophrenia: a review and meta-analysis. Neuropsychology Review, 11, 197–210. doi:10.1023/A:1012953108158.PubMedCrossRef Kurtz, M. M., Moberg, P. J., Gur, R. C., & Gur, R. E. (2001). Approaches to cognitive remediation of neuropsychological deficits in schizophrenia: a review and meta-analysis. Neuropsychology Review, 11, 197–210. doi:10.​1023/​A:​1012953108158.PubMedCrossRef
go back to reference Kurtz, M. M., Moberg, P. J., Gur, R. C., & Gur, R. E. (2004). Results from randomized, controlled trials of the effects of cognitive remediation on neurocognitive deficits in patients with schizophrenia. Psychological Medicine, 34, 569–570. doi:10.1017/S0033291704002016. comment.PubMedCrossRef Kurtz, M. M., Moberg, P. J., Gur, R. C., & Gur, R. E. (2004). Results from randomized, controlled trials of the effects of cognitive remediation on neurocognitive deficits in patients with schizophrenia. Psychological Medicine, 34, 569–570. doi:10.​1017/​S003329170400201​6. comment.PubMedCrossRef
go back to reference Kurtz, M. M., Seltzer, J. C., Fujimoto, M., Shagan, D. S., & Wexler, B. E. (2008a). Predictors of change in life skills in schizophrenia after cognitive remediation. Schizophrenia Research., . doi:10.1016/j.schres.2008.10.014. Kurtz, M. M., Seltzer, J. C., Fujimoto, M., Shagan, D. S., & Wexler, B. E. (2008a). Predictors of change in life skills in schizophrenia after cognitive remediation. Schizophrenia Research., . doi:10.​1016/​j.​schres.​2008.​10.​014.
go back to reference Kurtz, M. M., Wexler, B. E., Fujimoto, M., Shagan, D. S., & Seltzer, J. C. (2008b). Symptoms versus neurocognition as predictors of change in life skills in schizophrenia after outpatient rehabilitation. Schizophrenia Research, 102, 303–311. doi:10.1016/j.schres.2008.03.023.CrossRef Kurtz, M. M., Wexler, B. E., Fujimoto, M., Shagan, D. S., & Seltzer, J. C. (2008b). Symptoms versus neurocognition as predictors of change in life skills in schizophrenia after outpatient rehabilitation. Schizophrenia Research, 102, 303–311. doi:10.​1016/​j.​schres.​2008.​03.​023.CrossRef
go back to reference Lindenmayer, J., Kaushik, S., Branch, C., McGurk, S., Khan, A., Li, H., et al. (2008). Does computerized cognitive remediation change brain activation patterns in schizophrenia: fMRI pilot data. European Psychiatry, 23, S127–S128. doi:10.1016/j.eurpsy.2008.01.827.CrossRef Lindenmayer, J., Kaushik, S., Branch, C., McGurk, S., Khan, A., Li, H., et al. (2008). Does computerized cognitive remediation change brain activation patterns in schizophrenia: fMRI pilot data. European Psychiatry, 23, S127–S128. doi:10.​1016/​j.​eurpsy.​2008.​01.​827.CrossRef
go back to reference Maples, N. J., & Velligan, D. I. (2008). Cognitive adaptation training: establishing environmental supports to bypass cognitive deficits and improve functional outcomes. American Journal of Psychiatric Rehabilitation, 11, 164–180. doi:10.1080/15487760801963686.CrossRef Maples, N. J., & Velligan, D. I. (2008). Cognitive adaptation training: establishing environmental supports to bypass cognitive deficits and improve functional outcomes. American Journal of Psychiatric Rehabilitation, 11, 164–180. doi:10.​1080/​1548776080196368​6.CrossRef
go back to reference McGurk, S. R., Mueser, K. T., & Pascaris, A. (2005). Cognitive training and supported employment for persons with severe mental illness: one-year results from a randomized controlled trial. Schizophrenia Bulletin, 31, 898–909. doi:10.1093/schbul/sbi037.PubMedCrossRef McGurk, S. R., Mueser, K. T., & Pascaris, A. (2005). Cognitive training and supported employment for persons with severe mental illness: one-year results from a randomized controlled trial. Schizophrenia Bulletin, 31, 898–909. doi:10.​1093/​schbul/​sbi037.PubMedCrossRef
go back to reference McGurk, S. R., Mueser, K. T., Feldman, K., Wolfe, R., & Pascaris, A. (2007a). Cognitive training for supported employment: 2–3 year outcomes of a randomized controlled trial. The American Journal of Psychiatry, 164, 437–441. doi:10.1176/appi.ajp.164.3.437.CrossRef McGurk, S. R., Mueser, K. T., Feldman, K., Wolfe, R., & Pascaris, A. (2007a). Cognitive training for supported employment: 2–3 year outcomes of a randomized controlled trial. The American Journal of Psychiatry, 164, 437–441. doi:10.​1176/​appi.​ajp.​164.​3.​437.CrossRef
go back to reference Medalia, A., & Choi, J. (2009). The role of motivation and engagement in successful cognitive training with schizophrenia patients. Schizophrenia Bulletin, 35(sup 1), 355. Medalia, A., & Choi, J. (2009). The role of motivation and engagement in successful cognitive training with schizophrenia patients. Schizophrenia Bulletin, 35(sup 1), 355.
go back to reference Medalia, A., Revheim, N., & Casey, M. (2001). The remediation of problem-solving skills in schizophrenia. Schizophrenia Bulletin, 27, 259–267.PubMed Medalia, A., Revheim, N., & Casey, M. (2001). The remediation of problem-solving skills in schizophrenia. Schizophrenia Bulletin, 27, 259–267.PubMed
go back to reference Medalia, A., Herlands, T., & Baginsky, C. (2003). Rehab rounds: cognitive remediation in the supportive housing setting. Psychiatric Services (Washington, D.C.), 54, 1219–1220. doi:10.1176/appi.ps.54.9.1219. Medalia, A., Herlands, T., & Baginsky, C. (2003). Rehab rounds: cognitive remediation in the supportive housing setting. Psychiatric Services (Washington, D.C.), 54, 1219–1220. doi:10.​1176/​appi.​ps.​54.​9.​1219.
go back to reference Medalia, A., Revheim, N., & Herlands, T. (2009). Cognitive remediation for psychological disorders, therapist guide. New York: Oxford University Press. Medalia, A., Revheim, N., & Herlands, T. (2009). Cognitive remediation for psychological disorders, therapist guide. New York: Oxford University Press.
go back to reference Pilling, S., Bebbington, P., Kuipers, E., Garety, P., Geddes, J., Martindale, B., et al. (2002). Psychological treatments in schizophrenia: II. Meta-analyses of randomized controlled trials of social skills training and cognitive remediation. Psychological Medicine, 32, 783–791. see comment.PubMed Pilling, S., Bebbington, P., Kuipers, E., Garety, P., Geddes, J., Martindale, B., et al. (2002). Psychological treatments in schizophrenia: II. Meta-analyses of randomized controlled trials of social skills training and cognitive remediation. Psychological Medicine, 32, 783–791. see comment.PubMed
go back to reference Rohling, M. L., Faust, M. E., Beverly, B., & Demakis, G. (2009). Effectiveness of cognitive rehabilitation following acquired brain injury: a meta-analytic re-examination of Cicerone et al.’s (2000, 2005) systematic reviews. Neuropsychology, 23, 20–39. doi:10.1037/a0013659.PubMedCrossRef Rohling, M. L., Faust, M. E., Beverly, B., & Demakis, G. (2009). Effectiveness of cognitive rehabilitation following acquired brain injury: a meta-analytic re-examination of Cicerone et al.’s (2000, 2005) systematic reviews. Neuropsychology, 23, 20–39. doi:10.​1037/​a0013659.PubMedCrossRef
go back to reference Schunk, D. H. (2000). Self-theories and achievement motivation. In PsycCRITIQUES, pp. 554–556. Schunk, D. H. (2000). Self-theories and achievement motivation. In PsycCRITIQUES, pp. 554–556.
go back to reference Schunk, D. H. (2001). Social cognitive theory and self-regulated learning. New Jersey: Erlbaum. Schunk, D. H. (2001). Social cognitive theory and self-regulated learning. New Jersey: Erlbaum.
go back to reference Schunk, D. H. (2004). Continuing the controversy about reward and intrinsic motivation. In PsycCRITIQUES, pp. 532–534. Schunk, D. H. (2004). Continuing the controversy about reward and intrinsic motivation. In PsycCRITIQUES, pp. 532–534.
go back to reference Schunk, D. H., & Pajares, F. (2005). Competence perceptions and academic functioning. New York: Guilford. Schunk, D. H., & Pajares, F. (2005). Competence perceptions and academic functioning. New York: Guilford.
go back to reference Schunk, D. H., & Zimmerman, B. J. (2008). Motivation and self-regulated learning: Theory, research, and applications. New Jersey: Erlbaum. Schunk, D. H., & Zimmerman, B. J. (2008). Motivation and self-regulated learning: Theory, research, and applications. New Jersey: Erlbaum.
go back to reference Shuell, T. J. (1986). Cognitive conceptions of learning. Review of Educational Research, 56, 411–436. Shuell, T. J. (1986). Cognitive conceptions of learning. Review of Educational Research, 56, 411–436.
go back to reference Silverstein, S. M., & Wilkniss, S. (2004). The future of cognitive rehabilitation of schizophrenia. Schizophrenia Bulletin, 30, 679–692.PubMed Silverstein, S. M., & Wilkniss, S. (2004). The future of cognitive rehabilitation of schizophrenia. Schizophrenia Bulletin, 30, 679–692.PubMed
go back to reference Silverstein, S. M., Menditto, A. A., & Stuve, P. (2001). Shaping attention span: an operant conditioning procedure to improve neurocognition and functioning in schizophrenia. Schizophrenia Bulletin, 27, 247–257.PubMed Silverstein, S. M., Menditto, A. A., & Stuve, P. (2001). Shaping attention span: an operant conditioning procedure to improve neurocognition and functioning in schizophrenia. Schizophrenia Bulletin, 27, 247–257.PubMed
go back to reference Sitzer, D. I., Twamley, E. W., Patterson, T. L., & Jeste, D. V. (2008). Multivariate predictors of social skills performance in middle-aged and older out-patients with schizophrenia spectrum disorders. Psychological Medicine, 38, 755–763. doi:10.1017/S0033291707001304.PubMedCrossRef Sitzer, D. I., Twamley, E. W., Patterson, T. L., & Jeste, D. V. (2008). Multivariate predictors of social skills performance in middle-aged and older out-patients with schizophrenia spectrum disorders. Psychological Medicine, 38, 755–763. doi:10.​1017/​S003329170700130​4.PubMedCrossRef
go back to reference Spaulding, W. D., Reed, D., Sullivan, M., Richardson, C., & Weiler, M. (1999). Effects of cognitive treatment in psychiatric rehabilitation. Schizophrenia Bulletin, 25, 657–676.PubMed Spaulding, W. D., Reed, D., Sullivan, M., Richardson, C., & Weiler, M. (1999). Effects of cognitive treatment in psychiatric rehabilitation. Schizophrenia Bulletin, 25, 657–676.PubMed
go back to reference Twamley, E. W., Jeste, D. V., & Bellack, A. S. (2003). A review of cognitive training in schizophrenia. Schizophrenia Bulletin, 29, 359–382.PubMed Twamley, E. W., Jeste, D. V., & Bellack, A. S. (2003). A review of cognitive training in schizophrenia. Schizophrenia Bulletin, 29, 359–382.PubMed
go back to reference Twamley, E. W., Savla, G. N., Zurhellen, C. H., Heaton, R. K., & Jeste, D. V. (2008). Development and pilot testing of a novel compensatory cognitive training intervention for people with psychosis. American Journal of Psychiatric Rehabilitation, 11, 144–163. doi:10.1080/15487760801963678.PubMedCrossRef Twamley, E. W., Savla, G. N., Zurhellen, C. H., Heaton, R. K., & Jeste, D. V. (2008). Development and pilot testing of a novel compensatory cognitive training intervention for people with psychosis. American Journal of Psychiatric Rehabilitation, 11, 144–163. doi:10.​1080/​1548776080196367​8.PubMedCrossRef
go back to reference Vansteenkiste, M., Simons, J., Lens, W., Sheldon, K., & Deci, E. (2004). Motivating learning, performance, and persistence: the synergistic effects of intrinsic goal contents and autonomy-supportive contexts. Journal of Personality and Social Psychology, 87, 246–260. doi:10.1037/0022-3514.87.2.246.PubMedCrossRef Vansteenkiste, M., Simons, J., Lens, W., Sheldon, K., & Deci, E. (2004). Motivating learning, performance, and persistence: the synergistic effects of intrinsic goal contents and autonomy-supportive contexts. Journal of Personality and Social Psychology, 87, 246–260. doi:10.​1037/​0022-3514.​87.​2.​246.PubMedCrossRef
go back to reference Velligan, D. I., Bow-Thomas, C. C., Huntzinger, C., Ritch, J., Ledbetter, N., Prihoda, T. J., et al. (2000). Randomized controlled trial of the use of compensatory strategies to enhance adaptive functioning in outpatients with schizophrenia. The American Journal of Psychiatry, 157, 1317–1323. doi:10.1176/appi.ajp.157.8.1317.PubMedCrossRef Velligan, D. I., Bow-Thomas, C. C., Huntzinger, C., Ritch, J., Ledbetter, N., Prihoda, T. J., et al. (2000). Randomized controlled trial of the use of compensatory strategies to enhance adaptive functioning in outpatients with schizophrenia. The American Journal of Psychiatry, 157, 1317–1323. doi:10.​1176/​appi.​ajp.​157.​8.​1317.PubMedCrossRef
go back to reference Wexler, B. E., Anderson, M., Fulbright, R. K., & Gore, J. C. (2000). Preliminary evidence of improved verbal working memory performance and normalization of task-related frontal lobe activation in schizophrenia following cognitive exercises. The American Journal of Psychiatry, 157, 1694–1697. doi:10.1176/appi.ajp. 157.10.1694.PubMedCrossRef Wexler, B. E., Anderson, M., Fulbright, R. K., & Gore, J. C. (2000). Preliminary evidence of improved verbal working memory performance and normalization of task-related frontal lobe activation in schizophrenia following cognitive exercises. The American Journal of Psychiatry, 157, 1694–1697. doi:10.​1176/​appi.​ajp.​ 157.​10.​1694.PubMedCrossRef
go back to reference Wilk, C. M., Gold, J. M., Humber, K., Dickerson, F., Fenton, W. S., & Buchanan, R. W. (2004). Brief cognitive assessment in schizophrenia: normative data for the repeatable battery for the assessment of neuropsychological status. Schizophrenia Research, 70, 175–186. doi:10.1016/j.schres.2003.10.009.PubMedCrossRef Wilk, C. M., Gold, J. M., Humber, K., Dickerson, F., Fenton, W. S., & Buchanan, R. W. (2004). Brief cognitive assessment in schizophrenia: normative data for the repeatable battery for the assessment of neuropsychological status. Schizophrenia Research, 70, 175–186. doi:10.​1016/​j.​schres.​2003.​10.​009.PubMedCrossRef
go back to reference Wykes, T., Brammer, M., Mellers, J., Bray, P., Reeder, C., Williams, C., et al. (2002). Effects on the brain of a psychological treatment: cognitive remediation therapy: Functional magnetic resonance imaging in schizophrenia. The British Journal of Psychiatry, 181, 144–152.PubMed Wykes, T., Brammer, M., Mellers, J., Bray, P., Reeder, C., Williams, C., et al. (2002). Effects on the brain of a psychological treatment: cognitive remediation therapy: Functional magnetic resonance imaging in schizophrenia. The British Journal of Psychiatry, 181, 144–152.PubMed
go back to reference Wykes, T., Reeder, C., Williams, C., Corner, J., Rice, C., & Everitt, B. (2003). Are the effects of cognitive remediation therapy (CRT) durable? Results from an exploratory trial in schizophrenia. Schizophrenia Research, 61, 163–174. doi:10.1016/S0920-9964(02)00239-6.PubMedCrossRef Wykes, T., Reeder, C., Williams, C., Corner, J., Rice, C., & Everitt, B. (2003). Are the effects of cognitive remediation therapy (CRT) durable? Results from an exploratory trial in schizophrenia. Schizophrenia Research, 61, 163–174. doi:10.​1016/​S0920-9964(02)00239-6.PubMedCrossRef
go back to reference Wykes, T., Newton, E., Landau, S., Rice, C., Thompson, N., & Frangou, S. (2007a). Cognitive remediation therapy (CRT) for young early onset patients with schizophrenia: an exploratory randomized controlled trial. Schizophrenia Research, 94, 221–230. doi:10.1016/j.schres.2007.03.030.CrossRef Wykes, T., Newton, E., Landau, S., Rice, C., Thompson, N., & Frangou, S. (2007a). Cognitive remediation therapy (CRT) for young early onset patients with schizophrenia: an exploratory randomized controlled trial. Schizophrenia Research, 94, 221–230. doi:10.​1016/​j.​schres.​2007.​03.​030.CrossRef
go back to reference Wykes, T., Reeder, C., Landau, S., Everitt, B., Knapp, M., Patel, A., et al. (2007b). Cognitive remediation therapy in schizophrenia: randomised controlled trial. The British Journal of Psychiatry, 190, 421–427. doi:10.1192/bjp.bp.106.026575.CrossRef Wykes, T., Reeder, C., Landau, S., Everitt, B., Knapp, M., Patel, A., et al. (2007b). Cognitive remediation therapy in schizophrenia: randomised controlled trial. The British Journal of Psychiatry, 190, 421–427. doi:10.​1192/​bjp.​bp.​106.​026575.CrossRef
Metadata
Title
Cognitive Remediation in Schizophrenia
Authors
Alice Medalia
Jimmy Choi
Publication date
01-09-2009
Publisher
Springer US
Published in
Neuropsychology Review / Issue 3/2009
Print ISSN: 1040-7308
Electronic ISSN: 1573-6660
DOI
https://doi.org/10.1007/s11065-009-9097-y

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