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01-06-2007 | Original Paper

Meta-Analysis of Neuropsychological Symptoms of Adolescents and Adults with PKU

Authors: J. J. Moyle, A. M. Fox, M. Arthur, M. Bynevelt, J. R. Burnett

Published in: Neuropsychology Review | Issue 2/2007

Abstract

Phenylketonuria (PKU; OMIM 261600) is an autosomal recessive inborn error of phenylanaline metabolism. PKU is characterized by deficient or defective phenylalanine hydroxylase activity and persistantly increased levels of the essential amino acid phenylalanine in the circulation. The present article examines current understanding of the etiology of PKU, along with a meta-analysis examining neuropsychological and intellectual presentations in continuously treated adolescents and adults. Patients with PKU differed significantly from controls on Full-Scale IQ, processing speed, attention, inhibition, and motor control. Future research utilizing an integrative approach and detailed analysis of specific cognitive domains will assist both the scientist and clinician, and ultimately the patient.

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Title: Meta-Analysis of Neuropsychological Symptoms of Adolescents and Adults with PKU
Authors: J. J. Moyle
A. M. Fox
M. Arthur
M. Bynevelt
J. R. Burnett
Publication date: 01-06-2007
Publisher: Springer US
Published in: Neuropsychology Review / Issue 2/2007
Print ISSN: 1040-7308
Electronic ISSN: 1573-6660
DOI: https://doi.org/10.1007/s11065-007-9021-2

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Meta-Analysis of Neuropsychological Symptoms of Adolescents and Adults with PKU

Abstract

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Abstract

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