Top

Published in:

01-04-2019 | Clinical Study

Adaptation of visual cortex to damage of visual pathways in suprasellar tumors before and after gamma knife radiosurgery

Authors: Herwin Speckter, José Bido, Giancarlo Hernandez, Diones Rivera, Luis Suazo, Santiago Valenzuela, Remberto Escoto, Jairo Oviedo, Cesar F. Gonzalez, Bernd Foerster, Peter Stoeter

Published in: Journal of Neuro-Oncology | Issue 2/2019

Abstract

Purpose

To demonstrate that lesions of the visual pathways due to suprasellar tumors are accompanied by alterations of the visual cortex and to see if these alterations are reversible after treatment of tumors by gamma knife radiosurgery.

Materials and methods

In 36 patients with peri-optic tumors and defects of their visual fields and in an age-matched control group, magnetic resonance imaging was performed before and after treatment. T1 weighted images were evaluated by voxel-based morphometry and correlated to the degree of visual field defects.

Results

In patients, grey matter density and cortical thickness were reduced in all parts of the occipital cortex, reaching significance (p < 0.05) in the left superior and middle occipital gyri, with correlation to visual field defects. Follow-up scans showed further reduction in all occipital areas.

Conclusion

As in other peripheral lesions of the optic system, damage of the optic pathways affects the visual cortex. A prospective follow-up study is needed to determine if these alterations are reversible after successful tumor treatment.

Boucard CC, Hernowo AT, Maguire RP, Jansonius NM, Roerdink JB, Hooymans JM et al (2009) Changes in cortical grey matter density associated with long-standing retinal visual field defects. Brain 132:1898–1906. https://doi.org/10.1093/brain/awp119 CrossRefPubMedPubMedCentral

Frezzotti P, Giorgio A, Motolese I, De Leucio A, Iester M, Motolese E et al (2014) Structural and functional brain changes beyond visual system in patients with advanced glaucoma. PLoS ONE 9:e105931. https://doi.org/10.1371/journal.pone.0105931 CrossRefPubMedPubMedCentral

Prins D, Plank T, Baseler HA, Gouws AD, Beer A, Morland AB et al (2016) Surface-based analyses of anatomical properties of the visual cortex in macular degeneration. PLoS ONE 11:e0146684. https://doi.org/10.1371/journal.pone.0146684 CrossRefPubMedPubMedCentral

Brown HD, Woodall RL, Kitching RE, Baseler HA, Morland AB (2016) Using magnetic resonance imaging to assess visual deficits: a review. Ophthalmic Physiol Opt 36:240–265. https://doi.org/10.1111/opo.12293 CrossRefPubMedPubMedCentral

Burge WK, Griffis JC, Nenert R, Elkhetali A, DeCarlo DK, ver Hoef LW et al (2016) Cortical thickness in human V1 associated with central vision loss. Sci Rep 6:23268. https://doi.org/10.1038/srep23268 CrossRefPubMedPubMedCentral

Gupta N, Ang LC, Noel de Tilly L, Bidaisee L, Yucel YH (2006) Human glaucoma and neural degeneration in intracranial optic nerve, lateral geniculate nucleus, and visual cortex. Br J Ophthalmol 90:674–678CrossRefPubMedPubMedCentral

Barcella V, Rocca MA, Bianchi-Marzoli S, Milesi J, Melzi L, Falini A et al (2010) Evidence for retrochiasmatic tissue loss in Leber’s hereditary optic neuropathy. Hum Brain Mapp 31:1900–1906. https://doi.org/10.1002/hbm.20985 CrossRefPubMed

Mendola JD, Conner IP, Roy A, Chan ST, Schwartz TL, Odom JV et al (2005) Voxel-based analysis of MRI detects abnormal visual cortex in children and adults with amblyopia. Hum Brain Mapp 25:222–236CrossRefPubMed

Lemos J, Pereira D, Castelo-Branco M (2016) Visual cortex plasticity following peripheral damage to the visual system: fMRI evidence. Curr Neurol Neurosci Rep 16:89. https://doi.org/10.1007/s11910-016-0691-0 CrossRefPubMed

10.

Lou AR, Madsen KH, Julian HO, Toft PB, Kjaer TW, Paulson OB et al (2013) Postoperative increase in grey matter volume in visual cortex after unilateral cataract surgery. ActaOphthalmol 91:58–65. https://doi.org/10.1111/j.1755-3768.2011.02304.x CrossRef

11.

Shao Y, Keliris GA, Papanikolaou A, Fischer MD, Zobor D, Jägle H et al (2013) Visual cortex organisation in a macaque monkey with macular degeneration. Eur J Neurosci 38:3456–3464. https://doi.org/10.1111/ejn.12349 CrossRefPubMed

12.

Vernimmen FJ, Slabbert JP (2010) Assessment of the alpha/beta ratios for arteriovenous malformations, meningiomas, acoustic neuromas, and the optic chiasma. Int J Radiat Biol 86:486–498CrossRefPubMed

13.

Dahnke R, Yotter R, Gaser C (2012) Cortical thickness and central surface estimation. Neuroimage 65:336–348CrossRefPubMed

14.

Shattuck DW, Mirza M, Adisetiyo V, Hojatkashani C, Salamon G, Narr KL et al (2007) Construction of a 3D probabilistic atlas of human cortical structures. NeuroImage 39:1064–1080. https://doi.org/10.1016/j.neuroimage.2007.09.031 CrossRefPubMedPubMedCentral

15.

Desikan RS, Segonne F, Fischl B, Quinn BT, Dickerson BC, Blacker D et al (2006) An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest. Neuroimage 31:968–980. https://doi.org/10.1016/j.neuroimage.01.021 CrossRefPubMed

16.

Fischer E, Bülthoff HH, Logothetis NK, Bartels A (2012) Visual motion responses in the posterior cingulate sulcus: a comparison to V5/MT and MST. Cereb Cortex 22:865–76. https://doi.org/10.1093/cercor/bhr154 CrossRef

17.

Williams AL, Lackey J, Wizov SS, Chia TM, Gatla S, Moster ML et al (2013) Evidence for widespread structural brain changes in glaucoma: a preliminary voxel-based MRI study. Invest Ophthalmol Vis Sci 54:5880–5887CrossRefPubMed

18.

Hernowo AT, Prins D, Baseler HA, Plank T, Gouws AD, Hooymans JM et al (2014) Morphometric analyses of the visual pathways in macular degeneration. Cortex 56:99–110. https://doi.org/10.1016/j.cortex.2013.01.003 CrossRefPubMed

19.

Keenan TDL, Goldacre R, Goldacre MJ (2014) Associations between age-related macular degeneration, Alzheimer disease, and dementia. JAMA Ophthalmol 132:63–68CrossRefPubMed

20.

Kitajima M, Korogi Y, Hirai T, Hamatake S, Ikushima I, Sugahara T et al (1997) MR changes in the calcarine area resulting from retinal degeneration. AJNR Am J Neuroradiol 18:1291–1295PubMed

21.

Cheung SH, Legge GE (2005) Functional and cortical adaptations to central vision loss. Vis Neurosci 22:187–201CrossRefPubMedPubMedCentral

22.

Gennatas ED, Avants BB, Wolf DH, Satterthwaite TD, Ruparel K, Ciric R et al (2017) Age-related effects and sex differences in gray matter density, volume, mass, and cortical thickness from childhood to young adulthood. J Neurosci 37:5065–5073. https://doi.org/10.1523/JNEUROSCI.3550-16.2017 CrossRefPubMedPubMedCentral

23.

Guinan EM, Lowy C, Stanhope N, Lewis PD, Kopelman MD (1998) Cognitive effects of pituitary tumours and their treatments: two case studies and an investigation of 90 patients. J NeurolNeurosurg Psychiatry 65:870–876CrossRef

24.

Gaser C, Schlaug G (2003) Gray matter differences between musicians and nonmusicians. Ann N Y Acad Sci 999:514–517CrossRefPubMed

25.

Anurova I, Renier LA, De Volder AG, Carlson S, Rauschecker JP (2015) Relationship between cortical thickness and functional activation in the early blind. Cereb Cortex 25:2035–2048. https://doi.org/10.1093/cercor/bhu009 CrossRefPubMed

26.

Yuste R, Bonhoeffer T (2004) Genesis of dendritic spines: insights from ultrastructural and imaging studies. Nat Rev Neurosci 5:24–34CrossRefPubMed

27.

Voss P, Pike BG, Zatorre RJ (2014) Evidence for both compensatory plastic and disuse atrophy-related neuroanatomical changes in the blind. Brain 137:1224–1240. https://doi.org/10.1093/brain/awu030 CrossRefPubMed

28.

Gilbert CD, Li W (2012) Adult visual cortical plasticity. Neuron 75:250–264. https://doi.org/10.1016/j.neuron.2012.06.030 CrossRefPubMedPubMedCentral

Title: Adaptation of visual cortex to damage of visual pathways in suprasellar tumors before and after gamma knife radiosurgery
Authors: Herwin Speckter
José Bido
Giancarlo Hernandez
Diones Rivera
Luis Suazo
Santiago Valenzuela
Remberto Escoto
Jairo Oviedo
Cesar F. Gonzalez
Bernd Foerster
Peter Stoeter
Publication date: 01-04-2019
Publisher: Springer US
Published in: Journal of Neuro-Oncology / Issue 2/2019
Print ISSN: 0167-594X
Electronic ISSN: 1573-7373
DOI: https://doi.org/10.1007/s11060-019-03092-4

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Adaptation of visual cortex to damage of visual pathways in suprasellar tumors before and after gamma knife radiosurgery

Abstract

Purpose

Materials and methods

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Materials and methods

Results

Conclusion

Please log in to get access to this content

Other articles of this Issue 2/2019

Laser-interstitial thermal therapy compared to craniotomy for treatment of radiation necrosis or recurrent tumor in brain metastases failing radiosurgery

Clinical features, radiological profiles, and surgical outcomes of primary intracranial solitary plasmacytomas: a report of 17 cases and a pooled analysis of individual patient data

Incidental intracranial meningiomas: a systematic review and meta-analysis of prognostic factors and outcomes

MicroRNA regulating stanniocalcin-1 is a metastasis and dissemination promoting factor in glioblastoma

EGFR amplification and classical subtype are associated with a poor response to bevacizumab in recurrent glioblastoma

Correction to: Clinical features, radiological profiles, and surgical outcomes of primary intracranial solitary plasmacytomas: a report of 17 cases and a pooled analysis of individual patient data