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01-06-2019 | Meningioma | Clinical Study

Gamma knife radiosurgery for the treatment of cavernous sinus meningiomas: post-treatment long-term clinical outcomes, complications, and volume changes

Authors: Yi-Chieh Hung, Cheng-Chia Lee, Wan-Yuo Guo, Cheng-Ying Shiau, Yue-Cune Chang, David Hung-Chi Pan, Jason P. Sheehan, Wen-Yuh Chung

Published in: Journal of Neuro-Oncology | Issue 2/2019

Abstract

Purpose

To evaluate the outcomes of patients who underwent Gamma Knife radiosurgery (GKRS) for the treatment of cavernous sinus (CS) meningiomas.

Methods

We retrospectively reviewed the clinical and radiological outcomes of 95 patients with CS meningiomas at Taipei Veterans General Hospital between 1993 and 2011. The study cohort comprised 27 men and 68 women with a median age of 50 years (range 29–79 years). The median pre-GKRS tumor volume was 6.6 ml (range 0.9–35.7 ml). The median margin dose was 12 Gy (range 11–21 Gy). The clinical factors related to favorable outcomes were assessed.

Results

The median follow-up period was 59 (range 12–209) months. At the final follow-up, the tumor volume regressed in 70 patients (74%) and progressed in eight (8%). Kaplan–Meier analysis revealed that the progression-free survival rates at 5 and 10 years were 92.7% and 81.2%, respectively. Three patients (3.2%) experienced exacerbated cranial nerve dysfunction following radiosurgery. Confined tumors were found to be an independent prognostic factor for tumor control and shorter times to regression in the multivariable analyses. No risk factor for tumor progression was identified in either the univariate or multivariate analyses.

Conclusions

GKRS provides good long-term tumor control and is associated with low cranial nerve–related morbidity development rates in patients with small- to medium-sized CS meningiomas. Confined tumor could be an independent prognostic factor for tumor control and shorter times to regression in multivariate analysis. Life-long follow-up is mandatory in such settings, even for outpatients with shrunken or stabilized tumors.

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Title: Gamma knife radiosurgery for the treatment of cavernous sinus meningiomas: post-treatment long-term clinical outcomes, complications, and volume changes
Authors: Yi-Chieh Hung
Cheng-Chia Lee
Wan-Yuo Guo
Cheng-Ying Shiau
Yue-Cune Chang
David Hung-Chi Pan
Jason P. Sheehan
Wen-Yuh Chung
Publication date: 01-06-2019
Publisher: Springer US
Keywords: Meningioma
Meningioma
Published in: Journal of Neuro-Oncology / Issue 2/2019
Print ISSN: 0167-594X
Electronic ISSN: 1573-7373
DOI: https://doi.org/10.1007/s11060-019-03090-6

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Gamma knife radiosurgery for the treatment of cavernous sinus meningiomas: post-treatment long-term clinical outcomes, complications, and volume changes

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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