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01-12-2018 | Clinical Study

Clinical and prognostic features of spinal meningioma: a thorough analysis from a single neurosurgical center

Authors: Lingyang Hua, Hongda Zhu, Jiaojiao Deng, Mi Tian, Xuewei Jiang, Hailiang Tang, Shihai Luan, Hiroaki Wakimoto, Qing Xie, Ye Gong

Published in: Journal of Neuro-Oncology | Issue 3/2018

Abstract

Purpose

The aim of this study was to thoroughly analyze the clinical characteristics of a large cohort of spinal meningioma (SM) from a single neurological center and identify risk factors associated with worse progression free survival and neurological function outcome.

Methods

Clinical information was retrieved from 483 SM and 9806 cranial meningioma cases who were operated in our center between 2003 and 2013. 194 SM patients who were followed at the main branch were used for prognostic analyses that included both recurrence free survival and neurological functions based on Modified McCormick scale (MMS).

Results

Females were predominant (P < 0.001). High grade tumors were not common (WHO grade II, 2.9%; grade III, 1.7%), while the clear cell subtype was frequent within grade II SMs (6/14, 42.9%). Macroscopic total resection was achieved in all SMs (Simpson grade I, 30.9%; grade II, 65.5%; grade III, 3.6%) with a low complications rate (4.6%) and provided neurological improvement in 80 patients (41.2%). Recurrence was seen in 9 cases (4.6%) and associated with high WHO grade, male, prior recurrence, and Simpson grade III. High WHO grade and high Ki-67 index were identified to be independent factors predictive of both neurological function deterioration and impaired post-operative neurological status.

Conclusions

Our analysis of the largest SM cohort in scale from a single institution offers a comprehensive view of the clinical characteristics of surgically treated SM, revealing the distinct biology of SM in comparison to its cranial counterparts, and providing guidance to improve surgical management of SM.

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Title: Clinical and prognostic features of spinal meningioma: a thorough analysis from a single neurosurgical center
Authors: Lingyang Hua
Hongda Zhu
Jiaojiao Deng
Mi Tian
Xuewei Jiang
Hailiang Tang
Shihai Luan
Hiroaki Wakimoto
Qing Xie
Ye Gong
Publication date: 01-12-2018
Publisher: Springer US
Published in: Journal of Neuro-Oncology / Issue 3/2018
Print ISSN: 0167-594X
Electronic ISSN: 1573-7373
DOI: https://doi.org/10.1007/s11060-018-2993-3

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Clinical and prognostic features of spinal meningioma: a thorough analysis from a single neurosurgical center

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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