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01-09-2018 | Clinical Study

TERT promoter mutation is associated with worse prognosis in WHO grade II and III meningiomas

Authors: Annamaria Biczok, Theo Kraus, Bogdana Suchorska, Nicole A. Terpolilli, Jun Thorsteinsdottir, Armin Giese, Joerg C. Tonn, Christian Schichor

Published in: Journal of Neuro-Oncology | Issue 3/2018

Abstract

Introduction

Transcriptional activating mutations in the promoter region of the telomerase reverse transcriptase (TERT) gene occur at high frequency in various types of solid tumors and have also been reported for meningiomas. Especially for atypical and anaplastic meningiomas, the prognostic relevance of TERT promoter mutation is yet unclear. The present study aimed to analyze the frequency of TERT promoter mutation and define its long-term prognostic significance beyond clinical and histological factors in a cohort of meningiomas WHO grade II and III.

Methods

Patients undergoing surgical resection of aggressive meningiomas were included. Analysis for C228T and C250T mutation in the TERT promoter region was performed using PCR method. Patients were stratified into two groups (TERT mutated vs. TERT wild type). Univariate analysis was conducted using molecular and histological factors.

Results

87 patients with atypical (N = 72) and anaplastic meningiomas (N = 15) were included in the study. TERT promoter region was found to be mutated in 4 WHO grade II and 2 WHO grade III meningiomas. TERT promoter mutation was associated with shorter progression free survival than TERT wild type meningiomas (median PFS 12.5 vs. 26 months, p = .004). In the univariate analysis, TERT promoter mutation had a strong prognostic value on overall survival (p = .009) and progression free survival.

Conclusions

Presence of TERT promoter mutation is associated with shorter progression free survival and overall survival in meningiomas WHO grade II and III. In these tumors, TERT promoter mutation should be considered as a clinically relevant prognostic factor to identify high risk patients.

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Title: TERT promoter mutation is associated with worse prognosis in WHO grade II and III meningiomas
Authors: Annamaria Biczok
Theo Kraus
Bogdana Suchorska
Nicole A. Terpolilli
Jun Thorsteinsdottir
Armin Giese
Joerg C. Tonn
Christian Schichor
Publication date: 01-09-2018
Publisher: Springer US
Published in: Journal of Neuro-Oncology / Issue 3/2018
Print ISSN: 0167-594X
Electronic ISSN: 1573-7373
DOI: https://doi.org/10.1007/s11060-018-2912-7

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

TERT promoter mutation is associated with worse prognosis in WHO grade II and III meningiomas

Abstract

Introduction

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Introduction

Methods

Results

Conclusions

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